Structurally Diverse Triterpene-26-oic Acids as Potential Dual ACL and ACC1 Inhibitors from the Vulnerable Conifer Keteleeria fortunei
文献类型：期刊论文
| 作者 | Zhao, Ze-Yu2,3; Tong, Ying-Peng3; Jiang, Wei2,4; Zang, Yi1 ; Xiong, Juan2; Li, Jia1; Hu, Jin-Feng2,3
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2023-06-08 |
| 页码 | 13 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00181 |
| 通讯作者 | Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn) |
| 英文摘要 | A preliminaryphytochemical investigation on the 90%MeOH extractfrom the twigs and needles of the vulnerable conifer Keteleeriafortunei led to the isolation and characterization of 17structurally diverse triterpen-26-oic acids, including nine previouslyundescribed ones (fortunefuroic acids A-I, 1-9) featuring a rare furoic acid moiety in the lateral chain.Among them, 1-5 are uncommon 9 beta H-lanostane-type triterpenoic acids. Friedo-rearranged triterpenoids 6 and 7 feature a unique 17,14-friedo-lanostaneskeleton, whereas 9 possesses a rare 17,13-friedo-cycloartane-typeframework. Their structures and absolute configurations were elucidatedby extensive spectroscopic (e.g., detailed 2D NMR) and computational(NMR/ECD) calculations and the modified Mosher's method. Inaddition, the absolute structure of compound 1 was ascertainedby single-crystal X-ray diffraction analyses. Fortunefuroic acidsB (2), G (7), and I (9), alongwith isomangiferolic acid (12) and 3 alpha,27-dihydroxycycloart-24E-en-26-oic acid (14), exhibited dual inhibitoryeffects against the adenosine triphosphate (ATP)-citrate lyase (ACL,IC50s: 5.7-11.4 mu M) and acetyl-CoA carboxylase1 (ACC1, IC50s: 7.5-10.5 mu M), both of whichare key enzymes for glycolipid metabolism. The interactions of thebioactive triterpenoids with both enzymes were examined by moleculardocking studies. The above findings reveal the important role of protectingplant species diversity in support of chemical diversity and potentialsources of new therapeutics for ACL-/ACC1-associated diseases. |
| WOS关键词 | NATURAL-PRODUCTS ; ABIES-FAXONIANA ; TRITERPENOIDS ; CONSTITUENTS ; BARK ; PLANTS |
| 资助项目 | National Natural Science Foundation of China (NSFC)[21937002] ; National Natural Science Foundation of China (NSFC)[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001004372400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306257]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiong, Juan; Hu, Jin-Feng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 3.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Zhejiang, Peoples R China 4.Wuhan Polytech Univ, Sch Life Sci & Technol, Wuhan 430023, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ze-Yu,Tong, Ying-Peng,Jiang, Wei,et al. Structurally Diverse Triterpene-26-oic Acids as Potential Dual ACL and ACC1 Inhibitors from the Vulnerable Conifer Keteleeria fortunei[J]. JOURNAL OF NATURAL PRODUCTS,2023:13. |
| APA | Zhao, Ze-Yu.,Tong, Ying-Peng.,Jiang, Wei.,Zang, Yi.,Xiong, Juan.,...&Hu, Jin-Feng.(2023).Structurally Diverse Triterpene-26-oic Acids as Potential Dual ACL and ACC1 Inhibitors from the Vulnerable Conifer Keteleeria fortunei.JOURNAL OF NATURAL PRODUCTS,13. |
| MLA | Zhao, Ze-Yu,et al."Structurally Diverse Triterpene-26-oic Acids as Potential Dual ACL and ACC1 Inhibitors from the Vulnerable Conifer Keteleeria fortunei".JOURNAL OF NATURAL PRODUCTS (2023):13. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。