The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity
文献类型：期刊论文
| 作者 | Yan, Siqi1,2,3; Ke, Changqiang2,3 ; Feng, Zheling2,3; Tang, Chunping2,3; Ye, Yang1,2,3,4
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| 刊名 | MOLECULES
 |
| 出版日期 | 2023-05-22 |
| 卷号 | 28期号:10页码:14 |
| 关键词 | Artemisia divaricate sesquiterpene divaricanolide A-I anti-inflammatory activity |
| DOI | 10.3390/molecules28104254 |
| 通讯作者 | Tang, Chunping(tangcp@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn) |
| 英文摘要 | Artemisia divaricate belongs to the Artemisia genus of the family of Compositae, a sort of perennial herb endemic in most regions of China. For the first time, a phytochemical investigation was carried out on the whole plant of Artemisia divaricate, resulting in the identification of 39 sesquiterpenes, with 9 of them being new (1-9). The structures of the new compounds were fully established using extensive analysis of MS and 1D and 2D NMR spectroscopic data and density functional theory (DFT) NMR calculations. Their structures involve germacrane, eudesmane, and bisabolane types. All the new isolates were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages of RAW 264.7 cells. Compounds 2 and 8 showed a significant inhibition effect on NO production, with IC50 values of 5.35 +/- 0.75 and 7.68 +/- 0.54 mu M, respectively. |
| WOS关键词 | LACTONES ; DERIVATIVES ; SEEDS ; GENUS |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21920102003] ; Shanghai Pujiang Program[22PJD102] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000996789100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306263]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tang, Chunping; Ye, Yang |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Siqi,Ke, Changqiang,Feng, Zheling,et al. The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity[J]. MOLECULES,2023,28(10):14. |
| APA | Yan, Siqi,Ke, Changqiang,Feng, Zheling,Tang, Chunping,&Ye, Yang.(2023).The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity.MOLECULES,28(10),14. |
| MLA | Yan, Siqi,et al."The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity".MOLECULES 28.10(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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