Development of a Novel HER2-Targeted Peptide Probe for Dual-Modal Imaging of Tumors
文献类型：期刊论文
| 作者 | Cao, Rui3; Li, Renda3; Lai, Chaoquan1; Shi, Hui1; Liu, Hongguang3; Cheng, Zhen1,2 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2023-05-29 |
| 卷号 | 66期号:11页码:7523-7533 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.3c00347 |
| 通讯作者 | Shi, Hui(shihui@simm.ac.cn) ; Liu, Hongguang(simonliu@mail.neu.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Humanepidermal growth factor receptor 2 (HER2) may serveas avalid target for diagnosis of cancer. The probes with capability fornear-infrared window one region II (NIR-II) and positron emissiontomography (PET) dual-modal imaging are highly desired for HER2-positivetumor detection. Herein, three HER2-targeted peptides were designedand further modified with indocyanine green (ICG) and 2,2 ',2 '',2 ''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)-tetraaceticacid (DOTA), which were used for NIR-II imaging and complexation with Ga-68 for PET. Among the resulted probes (DOTA-ZC01-ICG, DOTA-KSP-ICG,and DOTA-ZC02-ICG), NIR-II imaging revealed that DOTA-ZC02-ICG hadthe best tumor imaging performance in SKOV3 tumor-bearing mice. Thehighest T/N ratio (5.4) was achieved at 4 h post-injection. Furthermore,DOTA-ZC02-ICG was radiolabeled with Ga-68 to generate [Ga-68]-DOTA-ZC02-ICG for PET, and it clearly delineated at 0.5,1, and 2 h post-injection. The tumor uptake reached 1.9 %ID/g at 0.5h, and the tumor uptakes were significantly inhibited in the blockingstudy (p < 0.05). Overall, it provides a promisingtechnique for tumor dual-modal imaging and a new molecular scaffoldfor developing HER2-targeted theranostic agents. |
| WOS关键词 | IN-VIVO ; CANCER ; NANOPARTICLES ; PERFORMANCE ; THERAPIES ; DIAGNOSIS ; PET |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; Shanghai Municipal Science and Technology Major Project[TM202301H003] ; Chinese Academy of Sciences |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001004185800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306269]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shi, Hui; Liu, Hongguang; Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang 110167, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Rui,Li, Renda,Lai, Chaoquan,et al. Development of a Novel HER2-Targeted Peptide Probe for Dual-Modal Imaging of Tumors[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023,66(11):7523-7533. |
| APA | Cao, Rui,Li, Renda,Lai, Chaoquan,Shi, Hui,Liu, Hongguang,&Cheng, Zhen.(2023).Development of a Novel HER2-Targeted Peptide Probe for Dual-Modal Imaging of Tumors.JOURNAL OF MEDICINAL CHEMISTRY,66(11),7523-7533. |
| MLA | Cao, Rui,et al."Development of a Novel HER2-Targeted Peptide Probe for Dual-Modal Imaging of Tumors".JOURNAL OF MEDICINAL CHEMISTRY 66.11(2023):7523-7533. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。