Forrestiacids E-K: Further [4+2]-Type Triterpene-Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii
文献类型：期刊论文
| 作者 | Zhou, Peng-Jun2,3; Huang, Ting3; Ma, Guang-Lei3; Tong, Ying-Peng2; Chen, Wen-Xue1; Zang, Yi4 ; Xiong, Juan3; Li, Jia4; Hu, Jin-Feng2,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2023-05-17 |
| 卷号 | 86期号:5页码:1251-1260 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00040 |
| 通讯作者 | Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@tzc.edu.cn) |
| 英文摘要 | Seven [4 + 2]-type triterpene-diterpene hybridsderivedfrom a rearranged or a normal lanostane unit (dienophile) and an abietanemoiety (diene), forrestiacids E-K (1-7, respectively), were further isolated and characterizedfrom Pseudotsuga forrestii (a vulnerable coniferendemic to China). The intriguing molecules were revealed with theguidance of an LC-MS/MS-based molecular ion networking strategy combinedwith conventional phytochemical procedures. Their chemical structureswith absolute configurations were established by spectroscopic data,chemical transformation, electronic circular dichroism calculations,and single-crystal X-ray diffraction analysis. They all contain arare bicyclo[2.2.2]-octene motif. Both forrestiacids J (6) and K (7) represent the first examples of this uniqueclass of [4 + 2]-type hybrids that arose from a normal lanostane-typedienophile. Some isolates remarkably inhibited ATP-citrate lyase (ACL),with IC50 values ranging from 1.8 to 11 mu M. Dockingstudies corroborated the findings by highlighting the interactionsbetween the bioactive compounds and the ACL enzyme (binding affinities:-9.9 to -10.7 kcal/mol). The above findings reveal theimportant role of protecting plant species diversity in support ofchemical diversity and potential sources of new therapeutics. |
| WOS关键词 | ATP-CITRATE LYASE ; DIELS-ALDER ADDUCTS ; MOLECULAR NETWORKING ; BEMPEDOIC ACID ; METABOLISM |
| 资助项目 | National Natural Science Foundation of China (NSFC)[21937002] ; National Natural Science Foundation of China (NSFC)[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001011814100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306275]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiong, Juan; Hu, Jin-Feng |
| 作者单位 | 1.Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China 2.Taizhou Univ, Inst Nat Med & Hlth Prod, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Zhejiang, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Peng-Jun,Huang, Ting,Ma, Guang-Lei,et al. Forrestiacids E-K: Further [4+2]-Type Triterpene-Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(5):1251-1260. |
| APA | Zhou, Peng-Jun.,Huang, Ting.,Ma, Guang-Lei.,Tong, Ying-Peng.,Chen, Wen-Xue.,...&Hu, Jin-Feng.(2023).Forrestiacids E-K: Further [4+2]-Type Triterpene-Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii.JOURNAL OF NATURAL PRODUCTS,86(5),1251-1260. |
| MLA | Zhou, Peng-Jun,et al."Forrestiacids E-K: Further [4+2]-Type Triterpene-Diterpene Hybrids as Potential ACL Inhibitors from the Vulnerable Conifer Pseudotsuga forrestii".JOURNAL OF NATURAL PRODUCTS 86.5(2023):1251-1260. |
入库方式： OAI收割
来源：上海药物研究所
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