Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus
文献类型：期刊论文
| 作者 | Zhou, Jun-Su2; Yao, Jia-Ying1,3; Gao, Yuan2; Liu, Qun-Fang2 ; Zhou, Bin2,4; He, Shi-Jun1; Zhao, Jin-Xin2,4; Yue, Jian-Min2,4
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2023-06-12 |
| 卷号 | 86期号:6页码:1606-1614 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00300 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Chemical investigation of the twigs of Cleistanthussumatranus (Phyllanthaceae) led to the isolation of 10 undescribedlignans,sumatranins A-J (1-10). Compounds 1-4 are unprecedented furopyran lignanscharacterized by a unique 2,3,3a,9a-tetrahydro-4H-furo[2,3-b]chromene heterotricyclic framework.Compounds 9 and 10 are rare 9 '-nor-dibenzylbutane lignans. Structures were establishedbased on analyses of spectroscopic data, X-ray crystallographic data,and experimental ECD spectra. Immunosuppressive assays revealed compounds 3 and 9 displayed moderate inhibitory effectswith good selectivity indexes against LPS-induced B lymphocyte proliferation. |
| WOS关键词 | DIBENZYLBUTANEDIOL LIGNANS ; DIBENZYLBUTYROLACTONE ; APOPTOSIS |
| 资助项目 | National Natural Science Foundation[22237007] ; National Natural Science Foundation[T2192972] ; Youth Innovation Promotion Association of CAS[2022282] ; Youth Innovation Promotion Association of CAS[KFJ-BRP-008-001] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001006268600001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306278]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Jun-Su,Yao, Jia-Ying,Gao, Yuan,et al. Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(6):1606-1614. |
| APA | Zhou, Jun-Su.,Yao, Jia-Ying.,Gao, Yuan.,Liu, Qun-Fang.,Zhou, Bin.,...&Yue, Jian-Min.(2023).Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus.JOURNAL OF NATURAL PRODUCTS,86(6),1606-1614. |
| MLA | Zhou, Jun-Su,et al."Sumatranins A-J: Lignans with Immunosuppressive Activity from Cleistanthus sumatranus".JOURNAL OF NATURAL PRODUCTS 86.6(2023):1606-1614. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。