GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy
文献类型：期刊论文
| 作者 | Huang, Xing2; He, Yihao2; Zhang, Miao2; Lu, Zhenhui3; Zhang, Tong1,2; Wang, Bing4,5 |
| 刊名 | EXPERT OPINION ON DRUG DELIVERY
 |
| 出版日期 | 2023-06-14 |
| 页码 | 19 |
| 关键词 | Photothermal therapy graphene oxide Timosaponin AIII melanoma mitochondria tumor therapy |
| ISSN号 | 1742-5247 |
| DOI | 10.1080/17425247.2023.2200997 |
| 通讯作者 | Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn) |
| 英文摘要 | BackgroundPhotothermal therapy (PTT) is a promising cancer treatment, but its application is limited by low photoconversion efficiency. In this study, we aimed to develop a novel graphene oxide (GO)-based nanocomposite hydrogel to improve the bioavailability of timosaponin AIII (TSAIII) while maximizing PTT efficacy and enhancing the antitumor effect.MethodsGO was modified via physical cross-linking with polyvinyl alcohol. The pore structure of the gel was adjusted by repeated freeze-thawing and the addition of polyethylene glycol 2000 to obtain a nanocomposite hydrogel (GPP). The GPP loaded with TSAIII constituted a GPP-TSAIII drug delivery system, and its efficacy was evaluated by in vitro cytotoxicity, apoptosis, migration, and uptake analyses, and in vivo antitumor studies.ResultsThe encapsulation rate of GPP-TSAIII was 66.36 +/- 3.97%, with slower in vitro release and higher tumor cell uptake (6.4-fold) compared to TSAIII. GPP-TSAIII in combination with PTT showed better bioavailability and antitumor effects in vivo than did TSAIII, with a 1.9-fold higher tumor suppression rate than the TSAIII group.ConclusionsGPP is a potential vehicle for delivery of TSAIII-like poor water-soluble anticancer drugs. The innovative PTT co-delivery system may serve as a safe and effective melanoma treatment platform for further anticancer translational purposes. |
| WOS关键词 | TIMOSAPONIN AIII ; PEGYLATED LIPOSOMES ; GRAPHENE OXIDE ; DRUG-DELIVERY ; IN-VITRO ; MITOCHONDRIA ; INJECTION |
| 资助项目 | National Science and Technology Major Project[2019ZX09201004-002] ; Key Project of Shanghai 3-year plan[ZY (2018-2020)-CCCX-2001-04] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001004923700001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306293]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Tong; Wang, Bing |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai lun Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Resp Dis, Long Hua Hosp, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 5.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Hai ke Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xing,He, Yihao,Zhang, Miao,et al. GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy[J]. EXPERT OPINION ON DRUG DELIVERY,2023:19. |
| APA | Huang, Xing,He, Yihao,Zhang, Miao,Lu, Zhenhui,Zhang, Tong,&Wang, Bing.(2023).GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy.EXPERT OPINION ON DRUG DELIVERY,19. |
| MLA | Huang, Xing,et al."GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy".EXPERT OPINION ON DRUG DELIVERY (2023):19. |
入库方式： OAI收割
来源：上海药物研究所
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