中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+tripeptide complex via activation of SIRT1 in airway epithelial cells

文献类型：期刊论文

作者Zhang, Qin1,3,4,5,6; Liu, Jia2; Deng, Ming-ming3,4,5,6; Tong, Run3,4,5,6; Hou, Gang3,4,5,6
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2023-08-01
卷号164页码:14
ISSN号0753-3322
关键词GHK GHK-Cu Airway remodeling Asthma SIRT1 Epithelial-mesenchymal transition
DOI10.1016/j.biopha.2023.114936
通讯作者Hou, Gang(hougang@zryhyy.com.cn)
英文摘要Fixed airflow limitation (FAO), prevalent in patients with severe or difficult-to-treat asthma, is mainly caused by airway remodeling. Airway remodeling is initiated by inflammation and involves subsequent pathological changes. Glycyl-L-histidyl-L-lysine (GHK) is a matrikine with anti-inflammatory and antioxidant effects, naturally existing in human tissue. At present, the GHK level in human plasma and whether it is related to airway remodeling of asthma remain unclear. This study was conducted to determine how GHK is involved in airway remodeling in asthma. Our result showed that the plasma GHK levels of patients with asthma were significantly lower than those of age-matched healthy controls. In asthma patients, plasma GHK levels display a moderate correlation with FEF25-75%, and patients with FAO had significantly lower GHK levels. Ovalbumin-induced mice of asthma model treated with PBS or GHK-Cu (a form of GHK with higher bioavailability) were used to evaluate the effect of exogenous GHK supplement on airway remodeling. GHK-Cu administration alleviated airway remodeling, as reflected by decreased peribronchial collagen deposition and airway mucus secretion, and suppressed epithelial-mesenchymal transition. The therapeutical effect related to decreased TGF-I31 level. Successively, network pharmacology and the validation data of experiments in vivo and vitro demonstrated that GHKCu decreased TGF-I31 level by increasing SIRT1 expression and activating SIRT1 deacetylation in airway epithelial cells, thereby alleviating airway remodeling. Collectively, decreased plasma GHK levels were related to FAO in asthma patients. Through the direct binding and activation of SIRT1, exogenous GHK-Cu administration alleviated airway remodeling in asthmatic mice.
WOS关键词MESENCHYMAL TRANSITION ; ASTHMA ; LYSINE ; TRIPEPTIDE ; PLASMA
资助项目National High Level Hospital Clinical Research Funding[2022-NHLHCRF-LX-01] ; Elite Medical Professionals project of China-Japan Friendship Hospital[ZRJY2021-BJ08] ; Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences[2020-PT320-001]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号WOS:001012628500001
源URL[http://119.78.100.183/handle/2S10ELR8/306313]  
专题中国科学院上海药物研究所
通讯作者Hou, Gang
作者单位1.China Med Univ, Inst Resp Dis, Hosp 1, 155 Nanjing St, Shenyang 110000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
3.China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, 2 East Yinghua Rd, Beijing 100029, Peoples R China
4.Chinese Acad Med Sci, Inst Resp Med, Beijing 100029, Peoples R China
5.Natl Clin Res Ctr Resp Dis, Beijing 100029, Peoples R China
6.China Japan Friendship Hosp, Natl Ctr Resp Med, Ctr Resp Med, 2 East Yinghua Rd, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Qin,Liu, Jia,Deng, Ming-ming,et al. Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+tripeptide complex via activation of SIRT1 in airway epithelial cells[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,164:14.
APA Zhang, Qin,Liu, Jia,Deng, Ming-ming,Tong, Run,&Hou, Gang.(2023).Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+tripeptide complex via activation of SIRT1 in airway epithelial cells.BIOMEDICINE & PHARMACOTHERAPY,164,14.
MLA Zhang, Qin,et al."Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+tripeptide complex via activation of SIRT1 in airway epithelial cells".BIOMEDICINE & PHARMACOTHERAPY 164(2023):14.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。