Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry
文献类型：期刊论文
| 作者 | Bao, Yandan3,4; Xing, Minyan1; Matthew, Naylor5; Chen, Xiaohua2,4 ; Wang, Xuan4; Lu, Xiaojie2,3,4
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023-06-29 |
| 页码 | 5 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.3c01817 |
| 通讯作者 | Wang, Xuan(wangxuan2@simm.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn) |
| 英文摘要 | While DNA-encoded macrocyclic libraries have gained substantialattention and several hit compounds have been identified from DNA-encodedlibrary technology, efficient on-DNA macrocyclic methods are alsorequired to construct DNA-linked libraries with a high degree of cyclizationand DNA integrity. In this paper, we reported a set of on-DNA methodologies,including the use of an OPA-mediated three-component cyclization withnative handles of amino acids and photoredox chemistries. These chemistriesproceed smoothly under mild conditions in good to excellent conversions,successfully generating novel isoindole, isoindoline, indazolone,and bicyclic scaffolds. |
| WOS关键词 | IN-VITRO ; LIBRARIES ; SELECTION ; PROTEINS ; DESIGN |
| 资助项目 | National Key Research and Development Program of China[NSFC-91953203] ; National Key Research and Development Program of China[NSFC-92253305] ; National Key Research and Development Program of China[2022YFC2804400] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001018961500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306325]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Xuan; Lu, Xiaojie |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China 5.UCB, Cambridge, MA 02140 USA |
| 推荐引用方式 GB/T 7714 | Bao, Yandan,Xing, Minyan,Matthew, Naylor,et al. Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry[J]. ORGANIC LETTERS,2023:5. |
| APA | Bao, Yandan,Xing, Minyan,Matthew, Naylor,Chen, Xiaohua,Wang, Xuan,&Lu, Xiaojie.(2023).Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry.ORGANIC LETTERS,5. |
| MLA | Bao, Yandan,et al."Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry".ORGANIC LETTERS (2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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