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Squamabietenols A-F, undescribed abietane-O-abietane dimeric diterpenoids from the ornamental conifer Juniperus squamata and their ATP-citrate lyase inhibitory activities

文献类型：期刊论文

作者Liang, Kai -Yuan2,3; Li, Hao2; Zhou, Peng-Jun2,3; Zhao, Ze-Yu2,3; Zang, Yi1; Xiong, Juan2; Li, Jia1; Hu, Jin-Feng2,3,4
刊名PHYTOCHEMISTRY
出版日期2023-06-01
卷号210页码:14
ISSN号0031-9422
关键词Juniperus squamata Buch -ham ex D don Cupressaceae Conifer Phytochemistry Chemotaxonomy Abietane O -Abietane Dimeric mono-diterpenoids Squamabietenols a -f ATP -Citrate lyase Molecular docking
DOI10.1016/j.phytochem.2023.113663
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@tzc.edu.cn)
英文摘要Six undescribed naturally occurring abietane-O-abietane dimers (squamabietenols A-F) together with one 3,4seco-totarane-type, a pimarane-type, and 17 related known mono-/dimeric diterpenoids were isolated and characterized from the needles and twigs of the ornamental conifer Juniperus squamata. The undescribed structures and their absolute configurations were established by extensive spectroscopic methods, GIAO NMR calculations with DP4+ probability analyses, and ECD calculations. Squamabietenols A and B showed significant inhibitory effects against ATP-citrate lyase (ACL, a novel drug target for hyperlipidemia and other metabolic disorders), with IC50 values of 8.82 and 4.49 & mu;M, respectively. A molecular docking study corroborated the findings by highlighting the interactions between the bioactive compounds and the ACL enzyme (binding affinities: -7.1 to -9.0 kcal/mol). The unique abietane-O-abietane dimeric diterpenoids are quite rare in the vegetable kingdom, and they are of chemotaxonomic significance for the Cupressaceae family.
WOS关键词PHYLOGENETIC-RELATIONSHIPS ; BARK ; CUPRESSACEAE ; SESQUITERPENES ; CONSTITUENTS ; TAXODIACEAE ; EXTRACTION ; HEARTWOOD ; LEAVES ; PLANTS
资助项目National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; Zhejiang Provincial Natural Science Foundation of China[LY23H300001]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:001011714600001
源URL[http://119.78.100.183/handle/2S10ELR8/306337]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
3.Taizhou Univ, Sch Pharmaceut Sci, Zhejiang Prov Key Lab Plant Evolutionary Ecol & Co, Taizhou 318000, Zhejiang, Peoples R China
4.Fudan Univ, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liang, Kai -Yuan,Li, Hao,Zhou, Peng-Jun,et al. Squamabietenols A-F, undescribed abietane-O-abietane dimeric diterpenoids from the ornamental conifer Juniperus squamata and their ATP-citrate lyase inhibitory activities[J]. PHYTOCHEMISTRY,2023,210:14.
APA Liang, Kai -Yuan.,Li, Hao.,Zhou, Peng-Jun.,Zhao, Ze-Yu.,Zang, Yi.,...&Hu, Jin-Feng.(2023).Squamabietenols A-F, undescribed abietane-O-abietane dimeric diterpenoids from the ornamental conifer Juniperus squamata and their ATP-citrate lyase inhibitory activities.PHYTOCHEMISTRY,210,14.
MLA Liang, Kai -Yuan,et al."Squamabietenols A-F, undescribed abietane-O-abietane dimeric diterpenoids from the ornamental conifer Juniperus squamata and their ATP-citrate lyase inhibitory activities".PHYTOCHEMISTRY 210(2023):14.

入库方式： OAI收割

来源：上海药物研究所

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