Solvent-Free Loading of Vitamin A Palmitate into beta-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement
文献类型：期刊论文
| 作者 | Zhang, Ying2,5; Chen, Jiacai4; Zhang, Zaiyong4; Zhu, Huajie2,5; Ma, Wuzhen4,5; Zhao, Xiangyu2,5; Wang, Manli4; Wang, Caifen4; Chen, Weidong2; Naeem, Abid1 |
| 刊名 | AAPS PHARMSCITECH
 |
| 出版日期 | 2023-06-12 |
| 卷号 | 24期号:5页码:11 |
| 关键词 | metal-organic frameworks molecular modeling solvent-free stability enhancement vitamin A palmitate |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-023-02596-7 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) ; Guo, Tao(guotao@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn) |
| 英文摘要 | Cyclodextrin metal-organic frameworks (CD-MOFs) exhibit a high structural diversity, which contributes to their functional properties. In this study, we have successfully synthesized a novel type of beta-cyclodextrin metal-organic framework (beta-CD-POF(I)) that exhibits excellent drug adsorption capacity and enhances stability. Single- crystal X-ray diffraction analysis revealed that beta-CD-POF(I) possessed the dicyclodextrin channel moieties and long-parallel tubular cavities. Compared with the reported beta-CD-MOFs, the beta-CD-POF(I) has a more promising drug encapsulation capability. Here, the stability of vitamin A palmitate (VAP) was effectively improved by the solvent-free method. Molecular modeling and other characterization techniques like synchrotron radiation Fourier transform infrared spectroscopy (SR-FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and nitrogen adsorption isotherm were applied to confirm that the VAP was successfully encapsulated into the channel formed by the dicyclodextrin pairs. Furthermore, the mechanism of stability enhancement for VAP was determined to be due to the constraint and separation effects of beta-CD pairs on VAP. Therefore, beta-CD-POF(I) is capable of trapping and stabilizing certain unstable drug molecules, offering benefits and application possibilities. |
| WOS关键词 | GAMMA-CYCLODEXTRIN ; RETINYL PALMITATE ; ENCAPSULATION ; DEGRADATION ; CARRIERS ; BINDING ; STORAGE |
| 资助项目 | National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001007539800001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306346]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen; Guo, Tao; Wu, Li |
| 作者单位 | 1.Jiangxi Univ Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Peoples R China 2.Anhui Univ Chinese Med, Hefei 230012, Peoples R China 3.Yantai Univ, Sch Pharm, Minist Educ, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China 5.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China 6.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ying,Chen, Jiacai,Zhang, Zaiyong,et al. Solvent-Free Loading of Vitamin A Palmitate into beta-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement[J]. AAPS PHARMSCITECH,2023,24(5):11. |
| APA | Zhang, Ying.,Chen, Jiacai.,Zhang, Zaiyong.,Zhu, Huajie.,Ma, Wuzhen.,...&Wu, Li.(2023).Solvent-Free Loading of Vitamin A Palmitate into beta-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement.AAPS PHARMSCITECH,24(5),11. |
| MLA | Zhang, Ying,et al."Solvent-Free Loading of Vitamin A Palmitate into beta-Cyclodextrin Metal-Organic Frameworks for Stability Enhancement".AAPS PHARMSCITECH 24.5(2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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