New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle
文献类型：期刊论文
| 作者 | Yu, Jia-Dong2,3,4; Yu, Dan-Dan5; Su, Ming-Zhi5; Gu, Yu-Cheng1; Wang, Hong2,3; Guo, Yue-Wei2,3,4,5
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 21期号:6页码:16 |
| 关键词 | soft coral Klyxum molle diterpenoids stereochemistry antibacterial activity |
| DOI | 10.3390/md21060362 |
| 通讯作者 | Wang, Hong(hongw@zjut.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 & mu;g/mL against Lactococcus garvieae. |
| WOS关键词 | EUNICELLIN-BASED DITERPENOIDS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001015191200001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306349]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 2.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 3.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jia-Dong,Yu, Dan-Dan,Su, Ming-Zhi,et al. New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle[J]. MARINE DRUGS,2023,21(6):16. |
| APA | Yu, Jia-Dong,Yu, Dan-Dan,Su, Ming-Zhi,Gu, Yu-Cheng,Wang, Hong,&Guo, Yue-Wei.(2023).New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle.MARINE DRUGS,21(6),16. |
| MLA | Yu, Jia-Dong,et al."New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle".MARINE DRUGS 21.6(2023):16. |
入库方式： OAI收割
来源：上海药物研究所
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