Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity
文献类型：期刊论文
| 作者 | Zhao, Ye2,3; Hua, Chen1; Sha, Yi-ou1; Wu, Pei-Qian2,3; Liu, Qun-Fang3 ; Lu, Lu1; Zhou, Bin3,4; Jiang, Shi-bo1; Fan, Yao-Yue3; Yue, Jian-Min2,3,4
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2023-09-01 |
| 卷号 | 213页码:11 |
| ISSN号 | 0031-9422 |
| 关键词 | Euphorbia lactea Haw Euphorbiaceae Diterpenoid Ingol Ent -pimarane Anti-HIV-1 |
| DOI | 10.1016/j.phytochem.2023.113745 |
| 通讯作者 | Jiang, Shi-bo(shibojiang@fudan.edu.cn) ; Fan, Yao-Yue(yyfan@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Nine undescribed diterpenoids, euphlactenoids A-I (1-9), including four ingol-type diterpenoids (1-4) with a 5/ 3/11/3-tetracyclic framework and five ent-pimarane-type diterpenoids (5-9), together with thirteen known diterpenoids (10-22), were identified from the leaves and stems of Euphorbia lactea Haw. The structures and absolute configurations of compounds 1-9 were unequivocally elucidated on the basis of spectroscopic analysis, ECD calculations and single crystal X-ray diffraction. Compounds 3 and 16 showed anti-HIV-1 effects with IC50 values of 1.17 & mu;M (SI = 16.54) and 13.10 & mu;M (SI = 1.93), respectively. |
| WOS关键词 | LATEX ; INHIBITION ; ESTERS |
| 资助项目 | National Natural Science Foundation[22237007] ; National Natural Science Foundation[82122062] ; National Natural Science Foundation[92169112] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program of Chinese Academy of Sciences[KFJ- BRP-008-001] ; Shanghai Municipal Science and Technology Major Project[ZD2021CY001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:001018592100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306352]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang, Shi-bo; Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai Publ Hlth Clin Ctr,MOE,NHC,CAMS,Biosafety, Sch Basic Med Sci,Shanghai Publ Hlth Clin Ctr,Key, Shanghai, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ye,Hua, Chen,Sha, Yi-ou,et al. Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity[J]. PHYTOCHEMISTRY,2023,213:11. |
| APA | Zhao, Ye.,Hua, Chen.,Sha, Yi-ou.,Wu, Pei-Qian.,Liu, Qun-Fang.,...&Yue, Jian-Min.(2023).Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity.PHYTOCHEMISTRY,213,11. |
| MLA | Zhao, Ye,et al."Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity".PHYTOCHEMISTRY 213(2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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