In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
文献类型：期刊论文
| 作者 | Du, Shichun2; Zhai, Linhui1,3; Ye, Shu1,2; Wang, Le1; Liu, Muyin4; Tan, Minjia1,3
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| 刊名 | SCIENCE CHINA-LIFE SCIENCES
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| 出版日期 | 2023-06-30 |
| 页码 | 17 |
| 关键词 | diabetic kidney disease type 2 diabetes mellitus urinary proteome urinary exosome proteome biomarkers |
| ISSN号 | 1674-7305 |
| DOI | 10.1007/s11427-022-2348-0 |
| 通讯作者 | Du, Shichun(dushichun@xinhuamed.com.cn) ; Tan, Minjia(mjtan@simm.ac.cn) |
| 英文摘要 | Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Monitoring the early diagnostic period and disease progression plays a crucial role in treating DKD. In this study, to comprehensively elucidate the molecular characteristics of urinary proteins and urinary exosome proteins in type 2 DKD, we performed large-scale urinary proteomics (n=144) and urinary exosome proteomics (n=44) analyses on T2DM patients with albuminuria in varying degrees. The dynamics analysis of the urinary and exosome proteomes in our study provides a valuable resource for discovering potential urinary biomarkers in patients with DKD. A series of potential biomarkers, such as SERPINA1 and transferrin (TF), were detected and validated to be used for DKD diagnosis or disease monitoring. The results of our study comprehensively elucidated the changes in the urinary proteome and revealed several potential biomarkers reflecting the progression of DKD, which provide a reference for DKD biomarker screening. |
| WOS关键词 | DIPEPTIDYL PEPTIDASE 4 ; NEPHROPATHY |
| 资助项目 | National Key Research and Development Program of China[2020YFE0202200] ; National Natural Science Foundation of China[22225702] ; National Natural Science Foundation of China[32071432] ; National Natural Science Foundation of China[32171434] ; National Natural Science Foundation of China[81600702] ; Program of Shanghai Academic Research Leader[22XD1420900] ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China[KF-202201] ; Innovative Research Team of High-Level Local Universities in Shanghai[SHSMU-ZDCX20212700] ; Guangdong High-level New Ramp;D Institute[2019B090904008] ; Guangdong High-level Innovative Research Institute[2021B0909050003] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001022515600001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306379]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Du, Shichun; Tan, Minjia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Dept Endocrinol, Xin Hua Hosp, Sch Med, Shanghai 200092, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Guangdong 528400, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Shichun,Zhai, Linhui,Ye, Shu,et al. In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease[J]. SCIENCE CHINA-LIFE SCIENCES,2023:17. |
| APA | Du, Shichun,Zhai, Linhui,Ye, Shu,Wang, Le,Liu, Muyin,&Tan, Minjia.(2023).In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease.SCIENCE CHINA-LIFE SCIENCES,17. |
| MLA | Du, Shichun,et al."In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease".SCIENCE CHINA-LIFE SCIENCES (2023):17. |
入库方式： OAI收割
来源：上海药物研究所
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