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"Platelet-coated bullets" biomimetic nanoparticles to ameliorate experimental colitis by targeting endothelial cells

文献类型：期刊论文

作者Song, Yijie1,2; He, Yihao1,3; Rong, Lan4; Wang, Zhicheng5; Ma, Yueming1; Zhang, Ning2; Wang, Bing3
刊名BIOMATERIALS ADVANCES
出版日期2023-05-01
卷号148页码:13
关键词Inflammatory bowel disease Patchouli alcohol Platelet mimetic nanoparticles
DOI10.1016/j.bioadv.2023.213378
通讯作者Ma, Yueming(mayueming@shutcm.edu.cn) ; Zhang, Ning(ningzhang@shutcm.edu.cn) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要Intestinal vascular impairment is critical to the recovery of inflammatory bowel disease (IBD), and targeting vascular endothelial cells is a promising emerging therapeutic option. Considering the natural homing properties of platelets to activated vascular endothelium, platelet membrane-mimetic nanoparticles are expected to achieve precise treatment of IBD. Patchouli alcohol (PA) has proven efficacy in experimental colitis, yet its pharmacochemical properties require improvement to enhance efficacy. The rationale for targeting vascular lesions in IBD was analyzed by network pharmacology, and PA-affecting pathways were predicted. PA-encapsulated bionanoparticles (PNPs) were constructed to investigate the efficacy of agents on mouse intestinal microvascular endothelial cells (MIMVEC) inflammation model and dextran sulfate sodium (DSS)-induced acute mouse colitis model. PNPs were endocytosed by MIMVEC in vitro and efficiently enriched in inflamed colon. PNPs significantly alleviated the symptoms of experimental colitis and improved neutrophil infiltration. PNPs downregulated LPS-induced aberrant elevation of il1 & beta;, tnf & alpha; and il6 mRNAs and reduced p65 phosphorylation in MIMVEC. Intracellular calcium expression, mitochondrial respiration and reactive oxygen species expression were also downregulated by PNPs. PNPs amplified the potency of PA as a calcium antagonist, restrained intracellular Ca2+ perturbations to prevent endothelial activation, which may block leukocyte recruitment in vivo to improve colitis.
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; ULCERATIVE-COLITIS ; BARRIER ; DELIVERY ; INFECTION ; CHANNELS ; IBD
资助项目Program of Shanghai Na-tional Natural Science Foundation, China[21ZR1475200]
WOS研究方向Materials Science
语种英语
出版者ELSEVIER
WOS记录号WOS:001027314600001
源URL[http://119.78.100.183/handle/2S10ELR8/306415]  
专题中国科学院上海药物研究所
通讯作者Ma, Yueming; Zhang, Ning; Wang, Bing
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai 201203, Peoples R China
4.Fudan Univ, Huashan Hosp, Dept Digest Dis, Shanghai 200040, Peoples R China
5.Fudan Univ, Huashan Hosp, Dept Transfus Med, Shanghai 200040, Peoples R China
推荐引用方式
GB/T 7714		 Song, Yijie,He, Yihao,Rong, Lan,et al. "Platelet-coated bullets" biomimetic nanoparticles to ameliorate experimental colitis by targeting endothelial cells[J]. BIOMATERIALS ADVANCES,2023,148:13.
APA Song, Yijie.,He, Yihao.,Rong, Lan.,Wang, Zhicheng.,Ma, Yueming.,...&Wang, Bing.(2023)."Platelet-coated bullets" biomimetic nanoparticles to ameliorate experimental colitis by targeting endothelial cells.BIOMATERIALS ADVANCES,148,13.
MLA Song, Yijie,et al.""Platelet-coated bullets" biomimetic nanoparticles to ameliorate experimental colitis by targeting endothelial cells".BIOMATERIALS ADVANCES 148(2023):13.

入库方式： OAI收割

来源：上海药物研究所

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