The development and benefits of metformin in various diseases
文献类型：期刊论文
| 作者 | Dong, Ying1; Qi, Yingbei1,5; Jiang, Haowen1; Mi, Tian1; Zhang, Yunkai1,2; Peng, Chang1,2; Li, Wanchen1,2; Zhang, Yongmei1,5; Zhou, Yubo1,7 ; Zang, Yi1,3,5
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| 刊名 | FRONTIERS OF MEDICINE
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| 出版日期 | 2023-07-04 |
| 页码 | 44 |
| 关键词 | metformin metabolism cancer aging neurological disorder |
| ISSN号 | 2095-0217 |
| DOI | 10.1007/s11684-023-0998-6 |
| 通讯作者 | Zhou, Yubo(ybzhou@simm.ac.cn) ; Zang, Yi(yzang@lglab.ac.cn) ; Li, Jia(jli@simm.ac.cn) |
| 英文摘要 | Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation of AMP-activated protein kinase (AMPK). Meanwhile, many novel targets of metformin have been gradually discovered. In recent years, multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes. Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological disorders. We comprehensively discussed the pharmacokinetic properties and the mechanisms of action, treatment strategies, the clinical application, the potential risk of metformin in various diseases. This review provides a brief summary of the benefits and concerns of metformin, aiming to interest scientists to consider and explore the common and specific mechanisms and guiding for the further research. Although there have been countless studies of metformin, longitudinal research in each field is still much warranted. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; STEADY-STATE PHARMACOKINETICS ; NF-KAPPA-B ; ORGANIC CATION TRANSPORTERS ; DIABETES PREVENTION PROGRAM ; REPROGRAMMED HUMAN NEURONS ; POLYCYSTIC-OVARY-SYNDROME ; SUPPRESSES TUMOR-GROWTH ; LIFE-STYLE INTERVENTION ; LONG-TERM METFORMIN |
| 资助项目 | China Postdoctoral Science Foundation[2021M703345] ; National Natural Science Foundation of China[82130099] ; National Natural Science Foundation of China[81971265] ; National Natural Science Foundation of China[81821055] ; National Natural Science Foundation of China[2022YFA1303802] ; Shanghai Science and Technology Development Funds[22YF1457100] ; Shanghai Science and Technology Development Funds[22ZR1415200] ; National Key Ramp;D Program of China[81821005] ; Lingang Laboratory[LG202103-03-04] ; Lingang Laboratory[LG202103-03-01] ; Lingang Laboratory[LG202103-03-05] |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001023661500001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306418]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yubo; Zang, Yi; Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Lingang Lab, Shanghai 201203, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China 5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 7.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Ying,Qi, Yingbei,Jiang, Haowen,et al. The development and benefits of metformin in various diseases[J]. FRONTIERS OF MEDICINE,2023:44. |
| APA | Dong, Ying.,Qi, Yingbei.,Jiang, Haowen.,Mi, Tian.,Zhang, Yunkai.,...&Li, Jia.(2023).The development and benefits of metformin in various diseases.FRONTIERS OF MEDICINE,44. |
| MLA | Dong, Ying,et al."The development and benefits of metformin in various diseases".FRONTIERS OF MEDICINE (2023):44. |
入库方式： OAI收割
来源：上海药物研究所
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