Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity
文献类型：期刊论文
| 作者 | Wu, Fengxia1,2; Chen, Haoran1; Li, Qiqing1; Liu, Ruiqi2; Suo, Yongkuan2; Li, Bin1; Kong, Xianggui1; Cheng, Zhen3,4; Liu, Hongguang2; Chang, Yulei1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2023-07-15 |
| 卷号 | 468页码:12 |
| ISSN号 | 1385-8947 |
| 关键词 | Lanthanide-doped nanoparticles Phototherapy Ferroptosis Immunogenic cell death NIR-IIb imaging Oxidative stress |
| DOI | 10.1016/j.cej.2023.143827 |
| 通讯作者 | Liu, Hongguang(simonliu@mail.neu.edu.cn) ; Chang, Yulei(yuleichang@ciomp.ac.cn) |
| 英文摘要 | Reactive oxygen species (ROS) are closely related to innate and adaptive immune responses in tumor immunotherapy. ROS-mediated therapies show great hope in improving therapeutic efficacy by inducing immunogenic cell death. However, the efficiency is still limited by the poor ROS production rate. Herein, a ROS nanogenerator is designed to boost antitumor immunity, integrating with pH-dissociable Fe3+-gallic acid (Fe-GA) complex as the shell and photosensitizer (Chlorin e6, Ce6)-coupled lanthanide-doped luminescence nanoparticles (LnNPs) as the core. Upon near-infrared (NIR) light irradiation, LnNPs exhibit multiband upconversion emission from ultraviolet (UV) to visible (Vis) and downshifting emission in the promising second NIR imaging region (NIR-II, 1550 nm). Especially, the UV photons and reducing agent GA could respectively mediate the reduction of Fe3+, allowing more Fe2+ to participate in the Fenton reaction to generate hydroxyl radicals (center dot OH) for ferroptosis therapy (FT). Besides, the UV-Vis upconversion emission can activate the coupling photosensitizer-Ce6 to generate O-1(2) for photodynamic therapy (PDT). Additionally, Fe-GA can serve as a photothermal therapy (PTT) agent; in turn, hyperthermia enhances ROS generation. Our rational-designed Ln@Fe NPs could not only enhance the synergistic antitumor efficiency by boosting ROS generation but also effectively inhibit tumor metastasis by activating strong antitumor immunity, providing a paradigm for imaging-guided cancer treatment. |
| WOS关键词 | IMMUNOTHERAPY |
| 资助项目 | National Key Research and Development Program of China[2021YFA0715603] ; National Natural Science Foundation of China[62075217] ; National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[11874354] ; National Natural Science Foundation of China[11874355] ; National Natural Science Foundation of China[61575194] ; National Natural Science Foundation of China[22172154] ; Project of Science and Technology Agency, Jilin Prov-ince[20210101148JC] ; Project of Science and Technology Agency, Jilin Prov-ince[202512JC010475440] ; Project of Science and Technology Agency, Jilin Prov-ince[20230508104RC] ; State Key Laboratory of Luminescence and Applications[SKLA-2019-02] ; State Key Laboratory of Luminescence and Applications[SKLA-2020-09] ; Shanghai Municipal Science and Technology Major Project[TM202301H003] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE SA |
| WOS记录号 | WOS:001013492200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306421]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hongguang; Chang, Yulei |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, Changchun 130033, Jilin, Peoples R China 2.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang 110169, Liaoning, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Fengxia,Chen, Haoran,Li, Qiqing,et al. Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity[J]. CHEMICAL ENGINEERING JOURNAL,2023,468:12. |
| APA | Wu, Fengxia.,Chen, Haoran.,Li, Qiqing.,Liu, Ruiqi.,Suo, Yongkuan.,...&Chang, Yulei.(2023).Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity.CHEMICAL ENGINEERING JOURNAL,468,12. |
| MLA | Wu, Fengxia,et al."Amplifying oxidative stress utilizing multiband luminescence of lanthanide nanoparticles for eliciting systemic antitumor immunity".CHEMICAL ENGINEERING JOURNAL 468(2023):12. |
入库方式： OAI收割
来源：上海药物研究所
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