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TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

文献类型：期刊论文

作者Zhang, Miao1,2,3,4; Ma, Yueming1; Ye, Xianglu5; Zhang, Ning2; Pan, Lei3,4,6; Wang, Bing1,7
刊名SIGNAL TRANSDUCTION AND TARGETED THERAPY
出版日期2023-07-05
卷号8期号:1页码:38
ISSN号2095-9907
DOI10.1038/s41392-023-01464-x
通讯作者Zhang, Ning(ningzh18@126.com) ; Pan, Lei(panlei@ips.ac.cn) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (Polycystin), TRPV (Vanilloid). They are a class of ion channels found in numerous tissues and cell types and are permeable to a wide range of cations such as Ca2+, Mg2+, Na+, K+, and others. TRP channels are responsible for various sensory responses including heat, cold, pain, stress, vision and taste and can be activated by a number of stimuli. Their predominantly location on the cell surface, their interaction with numerous physiological signaling pathways, and the unique crystal structure of TRP channels make TRPs attractive drug targets and implicate them in the treatment of a wide range of diseases. Here, we review the history of TRP channel discovery, summarize the structures and functions of the TRP ion channel family, and highlight the current understanding of the role of TRP channels in the pathogenesis of human disease. Most importantly, we describe TRP channel-related drug discovery, therapeutic interventions for diseases and the limitations of targeting TRP channels in potential clinical applications.
WOS关键词INFLAMMATORY-BOWEL-DISEASE ; POLYCYSTIC-KIDNEY-DISEASE ; ANKYRIN REPEAT DOMAIN ; NF-KAPPA-B ; ELECTRON CRYOMICROSCOPY STRUCTURE ; CRYOELECTRON MICROSCOPY STRUCTURE ; RANDOMIZED CLINICAL-TRIAL ; ACTIVATED PROTEIN-KINASE ; MAPK SIGNALING PATHWAYS ; VANILLOID 1 ANTAGONIST
资助项目National Key Research and Development Program of China[2022YFC2303504] ; Program of the Shanghai Committee of Science and Technology, China[21ZR1475200] ; Program of the Shanghai Committee of Science and Technology, China[22ZR1469900] ; National Natural Science Foundation of China[92157106] ; National Natural Science Foundation of China[32270917] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB16] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:001022943600001
源URL[http://119.78.100.183/handle/2S10ELR8/306433]  
专题中国科学院上海药物研究所
通讯作者Zhang, Ning; Pan, Lei; Wang, Bing
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Inst Pasteur Shanghai, Ctr Microbes Dev & Hlth, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China
6.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Ctr Pharmaceut Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Miao,Ma, Yueming,Ye, Xianglu,et al. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1):38.
APA Zhang, Miao,Ma, Yueming,Ye, Xianglu,Zhang, Ning,Pan, Lei,&Wang, Bing.(2023).TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1),38.
MLA Zhang, Miao,et al."TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023):38.

入库方式： OAI收割

来源：上海药物研究所

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