Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions
文献类型：期刊论文
| 作者 | He, Siyu1; Li, Linjie2; Jin, Rui2; Lu, Xiaojie2,3,4
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2023-07-13 |
| 卷号 | 66期号:14页码:9251-9277 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.3c00390 |
| 通讯作者 | Li, Linjie(linjieli816@163.com) ; Lu, Xiaojie(xjlu@simm.ac.cn) |
| 英文摘要 | Peptidyl-prolyl cis/trans isomerase family (PPIase) isstructurallydivided into three subfamilies, cyclophilins (Cyps), FK506-bindingproteins (FKBPs), and parvulins. Pin1 belongs to the parvulin familyand is the only enzyme capable of isomerizing the phosphorylated Ser/Thr-Promotif (p-Ser/Thr-Pro) in its interacting proteins. Due to its multibiologicalfunctions in vivo, including folding, intracellular signaling, transcription,cell cycle progression, and apoptosis, Pin1 is extensively studiedas a promising drug target for various human diseases, especiallycancer. In this Perspective, we summarized the literature coveringdiverse classes of Pin1 inhibitors and the inhibition mechanism, aimingto provide insights for the design of potent Pin1 inhibitors and suggestalternative strategies for developing potent Pin1 inhibitors. |
| WOS关键词 | PROLYL-ISOMERASE PIN1 ; ACUTE PROMYELOCYTIC LEUKEMIA ; STRUCTURE-BASED DESIGN ; NIMA-INTERACTING 1 ; TRANSCRIPTIONAL ACTIVITY ; BETA-CATENIN ; CELL-CYCLE ; PROTEIN-PHOSPHORYLATION ; SUBSTRATE RECOGNITION ; CONFORMATIONAL-CHANGE |
| 资助项目 | Shanghai Municipal Science and Technology Major Project[NSFC-91953203] ; Shanghai Municipal Science and Technology Major Project[NSFC-21877117] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001024839700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306439]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Linjie; Lu, Xiaojie |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Siyu,Li, Linjie,Jin, Rui,et al. Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023,66(14):9251-9277. |
| APA | He, Siyu,Li, Linjie,Jin, Rui,&Lu, Xiaojie.(2023).Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions.JOURNAL OF MEDICINAL CHEMISTRY,66(14),9251-9277. |
| MLA | He, Siyu,et al."Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions".JOURNAL OF MEDICINAL CHEMISTRY 66.14(2023):9251-9277. |
入库方式： OAI收割
来源：上海药物研究所
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