Recent advances of activation techniques-based discovery of new compounds from marine fungi
文献类型：期刊论文
| 作者 | Zou, Ran1; Chen, Bao3; Sun, Jie1; Guo, Yue-Wei2,3 ; Xu, Baofu1,2,3
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 167页码:14 |
| 关键词 | Marine fungi Silent Biosynthetic gene clusters Activation techniques |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2023.105503 |
| 通讯作者 | Xu, Baofu(bfxu@simm.ac.cn) |
| 英文摘要 | Natural products have been playing an indispensable role in drug discovery. However, it seems that the golden period of discovering new compounds has passed since the first antibiotic-penicillin. With the development of genome sequencing, it has been found that marine fungi contain various biosynthetic gene clusters (BGCs), which are silent under standard laboratory conditions. Therefore, it might be envisioned that once these BGCs are expressed, a large quantity of new secondary metabolites with biological activities could be generated. This paper reviewed several activation techniques implemented from 2020 to 2022, including epigenetics regulation, co-culture, precursor feeding, heterologous expression, and changing fermentation parameters to activate silent BGCs of marine fungi. We also described the diversity and bioactivities of these newly discovered uncommon marine fungi-derived compounds based on the classification of activation techniques, facilitating research groups focusing on natural products to enhance discovering efficiency. |
| WOS关键词 | NATURAL-PRODUCTS ; METHYLATION ; DIVERSITY ; IDENTIFY |
| 资助项目 | National Key Research and Devel- opment Program of China[2022YFC2804100] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000983162300001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306475]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Baofu |
| 作者单位 | 1.Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Ran,Chen, Bao,Sun, Jie,et al. Recent advances of activation techniques-based discovery of new compounds from marine fungi[J]. FITOTERAPIA,2023,167:14. |
| APA | Zou, Ran,Chen, Bao,Sun, Jie,Guo, Yue-Wei,&Xu, Baofu.(2023).Recent advances of activation techniques-based discovery of new compounds from marine fungi.FITOTERAPIA,167,14. |
| MLA | Zou, Ran,et al."Recent advances of activation techniques-based discovery of new compounds from marine fungi".FITOTERAPIA 167(2023):14. |
入库方式： OAI收割
来源：上海药物研究所
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