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Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles

文献类型：期刊论文

作者Gao, Ju1,2; Luo, Keyu2,3,4; Wei, Xiaohui2; Wang, Hao2; Liu, Hong1,2,4; Zhou, Yu2,3
刊名ORGANIC LETTERS
出版日期2023-05-05
页码6
ISSN号1523-7060
DOI10.1021/acs.orglett.3c00445
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要Rh(III)-catalyzed successive C-H activations of 2-phenyl-3H-indoles and cyclization cascades with diazo compounds were developed to construct highly fused indole heteropolycycles with a broad range of substrates and good yields. In particular, this transformation included two successive C-H activations and unusual [3+3] and [4+2] sequential cyclization cascades, in which the diazo compound played a different role in the two cyclization processes, while simultaneously forming a highly fused polycyclic indole scaffold with a new quaternary carbon center.
WOS关键词ENANTIOSELECTIVE TOTAL-SYNTHESIS ; PYRIDINE N-OXIDES ; DIAZO-COMPOUNDS ; REGIOSELECTIVE SYNTHESIS ; FUNCTIONALIZATION ; DEAROMATIZATION ; CARBAZOLES ; ANNULATION ; ALKALOIDS ; VINDOLINE
资助项目National Natural Science Foundation of China[82173656] ; National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[82151219]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000984576300001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/306481]  
专题中国科学院上海药物研究所
通讯作者Liu, Hong; Zhou, Yu
作者单位1.Weifang Med Coll, Coll Pharm, Weifang 261053, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Ju,Luo, Keyu,Wei, Xiaohui,et al. Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles[J]. ORGANIC LETTERS,2023:6.
APA Gao, Ju,Luo, Keyu,Wei, Xiaohui,Wang, Hao,Liu, Hong,&Zhou, Yu.(2023).Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles.ORGANIC LETTERS,6.
MLA Gao, Ju,et al."Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles".ORGANIC LETTERS (2023):6.

入库方式： OAI收割

来源：上海药物研究所

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