Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus
文献类型：期刊论文
| 作者 | Wang, Cheng-Lei1,2; Dai, Yang1; Zhu, Qiong1,2; Peng, Xia1; Liu, Quan-Fang1; Ai, Jing1,2 ; Zhou, Bin1; Yue, Jian-Min1,2,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2023-05-09 |
| 页码 | 15 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.3c00173 |
| 通讯作者 | Ai, Jing(jai@simm.ac.cn) ; Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Laeviganoids A-T (1-20), 20 new ent-clerodane-type diterpenoids featuring a 2-furanone (1-3) or a furan (4-20) ring, as well as six analogues (21-26), were isolated from the roots of Croton laevigatus. Their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallographic studies. Compounds 4-6, 16, 21-24, and 26 could influence the antiinflammatory protumoral phenotype of macrophages. Among these compounds, 21 and 26 are the most potent, as evidenced by consistently downregulating the classic anti-inflammatory cytokine IL-10 and upregulating the classic pro-inflammatory cytokine TNF-alpha on the secretion level in RAW 264.7 cells. |
| WOS关键词 | CONSTITUENTS |
| 资助项目 | National Natural Science Foundation[22237007] ; National Natural Science Foundation[82293685] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program, CAS[KFJ-BRP-008-001] ; Natural Science Foundation of China for Innovation Research Group[81821005] ; Collaborative Innovation Cluster Project of Shanghai Municipal Commission of Health and Family Planning[2020CXJQ02] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000985470300001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306490]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ai, Jing; Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Beijing 100700, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Cheng-Lei,Dai, Yang,Zhu, Qiong,et al. Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus[J]. JOURNAL OF NATURAL PRODUCTS,2023:15. |
| APA | Wang, Cheng-Lei.,Dai, Yang.,Zhu, Qiong.,Peng, Xia.,Liu, Quan-Fang.,...&Yue, Jian-Min.(2023).Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus.JOURNAL OF NATURAL PRODUCTS,15. |
| MLA | Wang, Cheng-Lei,et al."Laeviganoids A-T, ent-Clerodane-Type Diterpenoids from Croton laevigatus".JOURNAL OF NATURAL PRODUCTS (2023):15. |
入库方式： OAI收割
来源：上海药物研究所
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