Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity
文献类型：期刊论文
| 作者 | Sun, Li-Li1; Shen, Yi-Ran1; Li, Jia1,2 ; Wang, Jian-Rong1; Li, Xu-Wen1,2; Guo, Yue-Wei1,2
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2023-05-12 |
| 卷号 | 137页码:5 |
| 关键词 | Sponge Hyrtios erecta Scalarane-type sesterterpene Configuration PTP1B |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2023.133388 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Three new scalarane-type sesterterpenes, namely Hyrtiosins H-J (1-3), along with thirteen known related compounds (4-16), were isolated from the South China Sea sponge Hyrtios erecta. Their struc-tures were elucidated by extensive spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. The stereochemistry of heteronemin (9) was determined for the first time by X-ray crystallography study using Cu Ka radiation. In bioassay, compound 5 and 10 displayed considerable inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B) enzyme with IC50 values of 19.68 mM, and 8.81 mM, respectively.(c) 2023 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MARINE SPONGE ; ANTINEOPLASTIC AGENTS ; SESQUITERPENES |
| 资助项目 | National Key Research and Development Program of China[2022YFC2804100] ; National Key Research and Development Program of China[2021YFF0502400] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[Y202065] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000986812900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306505]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Li-Li,Shen, Yi-Ran,Li, Jia,et al. Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity[J]. TETRAHEDRON,2023,137:5. |
| APA | Sun, Li-Li,Shen, Yi-Ran,Li, Jia,Wang, Jian-Rong,Li, Xu-Wen,&Guo, Yue-Wei.(2023).Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity.TETRAHEDRON,137,5. |
| MLA | Sun, Li-Li,et al."Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity".TETRAHEDRON 137(2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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