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Cell penetrating peptides: Highlighting points in cancer therapy

文献类型：期刊论文

作者Asrorov, Akmal M.1,2,3,7; Wang, Huiyuan1; Zhang, Meng1; Wang, Yonghui1; He, Yang1; Sharipov, Mirkomil; Yili, Abulimiti4; Huang, Yongzhuo1,5,6
刊名DRUG DEVELOPMENT RESEARCH
出版日期2023-05-17
页码35
关键词amphipathic peptides cationic peptides cell-penetrating peptides cyclic peptides hydrophobic peptides polyarginines
ISSN号0272-4391
DOI10.1002/ddr.22076
通讯作者Asrorov, Akmal M.(akmal84a@gmail.com)
英文摘要Cell-penetrating peptides (CPPs), first identified in HIV a few decades ago, deserved great attention in the last two decades; especially to support the penetration of anticancer drug means. In the drug delivery discipline, they have been involved in various approaches from mixing with hydrophobic drugs to the use of genetically conjugated proteins. The early classification as cationic and amphipathic CPPs has been extended to a few more classes such as hydrophobic and cyclic CPPs so far. Developing potential sequences utilized almost all methods of modern science: choosing high-efficiency peptides from natural protein sequences, sequence-based comparison, amino acid substitution, obtaining chemical and/or genetic conjugations, in silico approaches, in vitro analysis, animal experiments, etc. The bottleneck effect in this discipline reveals the complications that modern science faces in drug delivery research. Most CPP-based drug delivery systems (DDSs) efficiently inhibited tumor volume and weight in mice, but only in rare cases reduced their levels and continued further processes. The integration of chemical synthesis into the development of CPPs made a significant contribution and even reached the clinical stage as a diagnostic tool. But constrained efforts still face serious problems in overcoming biobarriers to reach further achievements. In this work, we reviewed the roles of CPPs in anticancer drug delivery, focusing on their amino acid composition and sequences. As the most suitable point, we relied on significant changes in tumor volume in mice resulting from CPPs. We provide a review of individual CPPs and/or their derivatives in a separate subsection.
WOS关键词MOLECULAR-WEIGHT PROTAMINE ; DUAL-FUNCTIONAL LIPOSOMES ; ENHANCED INTRACELLULAR DELIVERY ; PROTEIN TRANSDUCTION DOMAINS ; PH-SENSITIVE LIPOSOMES ; PRO-APOPTOTIC PEPTIDE ; CYCLIC RGD PEPTIDE ; DRUG-DELIVERY ; BREAST-CANCER ; IN-VITRO
资助项目CAS President's International Fellowship Initiative ; Belt and Road Yong Scientist Program ; National Key Research and Development Program of China[2021YFE0103100] ; National Nature Science Foundation of China[8201101172] ; National Nature Science Foundation of China[81521005] ; National Nature Science Foundation of China[81925035] ; Shanghai Sci-Tech Innovation Initiative[19431903100] ; Shanghai Sci-Tech Innovation Initiative[18430740800] ; Sanofi-SIBS Yong Faculty Award
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000989594900001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/306511]  
专题新药研究国家重点实验室
通讯作者Asrorov, Akmal M.
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
2.AS Uzbekistan, Inst Bioorgan Chem, Tashkent, Uzbekistan
3.Natl Univ Uzbekistan, Dept Nat Subst Chem, Tashkent, Uzbekistan
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Xinjiang, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan, Peoples R China
6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Asrorov, Akmal M.,Wang, Huiyuan,Zhang, Meng,et al. Cell penetrating peptides: Highlighting points in cancer therapy[J]. DRUG DEVELOPMENT RESEARCH,2023:35.
APA Asrorov, Akmal M..,Wang, Huiyuan.,Zhang, Meng.,Wang, Yonghui.,He, Yang.,...&Huang, Yongzhuo.(2023).Cell penetrating peptides: Highlighting points in cancer therapy.DRUG DEVELOPMENT RESEARCH,35.
MLA Asrorov, Akmal M.,et al."Cell penetrating peptides: Highlighting points in cancer therapy".DRUG DEVELOPMENT RESEARCH (2023):35.

入库方式： OAI收割

来源：上海药物研究所

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