Ratiometric sensing of beta-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement
文献类型：期刊论文
| 作者 | Tian Jr, He2; Lin, Wei2; Hu, Xi-Le2; Wang, Jing-Bo2; Zhang, Min-Yu2; Zang, Yi1,3,7 ; Wu, Xin-Yan2; Li, Jia1,3; James, Tony D.5,6; He, Xiao-Peng2,4
|
| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2023-06-13 |
| 卷号 | 10期号:12页码:2913-2917 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d3qo00605k |
| 通讯作者 | Li, Jia(jli@simm.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) ; He, Xiao-Peng(xphe@ecust.edu.cn) |
| 英文摘要 | Glycosidases play important roles in modulating the structural and functional integrity of glycoproteins and glycolipids, and thus are promising biomarkers for disease diagnosis. While current approaches for glycosidase detection mainly rely on an enhancement of the UV-vis absorbance or fluorescence emission of glycosyl indicators, here we develop a ratiometric fluorescent probe for the sensitive and selective detection of glycosidase activity based on the combined mechanisms of excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement (SSLE). The probe behaves like a typical SSLE when glycosylated, and exhibits a similar to 140 nm red-shift in fluorescence owing to activation of ESIPT after deglycosylation. Such a large Stokes shift may facilitate the unbiased analysis of glycosidase activities when used in diagnostic and drug-screening assays. |
| WOS关键词 | FLUORESCENT-PROBE ; INDUCED-EMISSION ; AIE ; VISUALIZATION ; MECHANISMS ; TRACKING |
| 资助项目 | Natural National Science Foundation of China[91853201] ; Natural National Science Foundation of China[92253306] ; Natural National Science Foundation of China[82151219] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000988145000001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306523]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jia; James, Tony D.; He, Xiao-Peng |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China 5.Univ Bath, Dept Chem, Bath BA2 7AY, England 6.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China 7.Lingang Lab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian Jr, He,Lin, Wei,Hu, Xi-Le,et al. Ratiometric sensing of beta-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement[J]. ORGANIC CHEMISTRY FRONTIERS,2023,10(12):2913-2917. |
| APA | Tian Jr, He.,Lin, Wei.,Hu, Xi-Le.,Wang, Jing-Bo.,Zhang, Min-Yu.,...&He, Xiao-Peng.(2023).Ratiometric sensing of beta-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement.ORGANIC CHEMISTRY FRONTIERS,10(12),2913-2917. |
| MLA | Tian Jr, He,et al."Ratiometric sensing of beta-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement".ORGANIC CHEMISTRY FRONTIERS 10.12(2023):2913-2917. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。