中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins

文献类型：期刊论文

作者Wang, Yue2,3; Liu, Weiyi2,3; Xu, Youwei2; He, Xinheng2,3; Yuan, Qingning2; Luo, Ping2; Fan, Wenjia2,4; Zhu, Jingpeng2; Zhang, Xinyue2; Cheng, Xi2,3
刊名NATURE CHEMICAL BIOLOGY
出版日期2023-05-11
页码26
ISSN号1552-4450
DOI10.1038/s41589-023-01339-w
通讯作者Xu, H. Eric(Eric.Xu@simm.ac.cn) ; Zhuang, Youwen(zhuangyouwen@simm.ac.cn)
英文摘要The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations of C3aR and C5aR1 signaling lead to multiple inflammatory disorders, including sepsis, asthma and acute respiratory distress syndrome. The mechanism underlying endogenous anaphylatoxin recognition and activation of C3aR and C5aR1 remains elusive. Here we reported the structures of C3a-bound C3aR and C5a-bound C5aR1 as well as an apo-C3aR structure. These structures, combined with mutagenesis analysis, reveal a conserved recognition pattern of anaphylatoxins to the complement receptors that is different from chemokine receptors, unique pocket topologies of C3aR and C5aR1 that mediate ligand selectivity, and a common mechanism of receptor activation. These results provide crucial insights into the molecular understanding of C3aR and C5aR1 signaling and structural templates for rational drug design for treating inflammation disorders.
WOS关键词BINDING-SITE ; 2-SITE BINDING ; IDENTIFICATION ; SYSTEM ; ACTIVATION ; RESIDUES
资助项目Special Research Assistant Project of the Chinese Academy of Sciences ; Sailing Program of Shanghai Venus Project[23YF1456700] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2023298] ; Natural Science Foundation of Shanghai, China[23ZR1475300] ; CAS Strategic Priority Research Program[XDB37030103] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; National Natural Science Foundation of China[32130022] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[32171187] ; National Key R&D Program of China[2018YFA0507002]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000986854600002
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/306539]  
专题新药研究国家重点实验室
通讯作者Xu, H. Eric; Zhuang, Youwen
作者单位1.Lingang Lab, Shanghai, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Struct & Funct Drug Targets, State Key Lab Drug Res, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yue,Liu, Weiyi,Xu, Youwei,et al. Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins[J]. NATURE CHEMICAL BIOLOGY,2023:26.
APA Wang, Yue.,Liu, Weiyi.,Xu, Youwei.,He, Xinheng.,Yuan, Qingning.,...&Zhuang, Youwen.(2023).Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.NATURE CHEMICAL BIOLOGY,26.
MLA Wang, Yue,et al."Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins".NATURE CHEMICAL BIOLOGY (2023):26.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。