Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites
文献类型：期刊论文
| 作者 | He, Xin2,3; Nie, Min2,3; Wang, Mengyuan3; Wu, Shifei3; Wei, Xuemei3; Li, Jiayuan3; Yao, Changliang3; Wang, Chao1; Ma, Xiaochi1; Guo, De-an2,3,4
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 167页码:6 |
| ISSN号 | 0367-326X |
| 关键词 | Osthole Microbial transformation Mucor circinelloides Anti -osteoporosis activity |
| DOI | 10.1016/j.fitote.2023.105510 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Osthole is one of the major constituents in Cnidium monnieri (L.) Cuss. and possesses anti-osteoporosis activity. In this work, the biotransformation of osthole was performed based on the human intestinal fungi Mucor circi-nelloides. Six metabolites including three new metabolites (S2, S3, S4) were obtained, and their chemical structures were elucidated by spectroscopic data analysis. The major biotransformation reactions involved hy-droxylation and glycosylation. In addition, all metabolites were evaluated for their anti-osteoporosis activity using MC3T3-E1 cells. The results demonstrated that S4, S5 and S6 could significantly promote MC3T3-E1 cell growth compared to osthole. |
| WOS关键词 | CNIDIUM-MONNIERI ; COUMARINS ; BIOTRANSFORMATION ; DIFFERENTIATION |
| 资助项目 | National Natural Science Foundation of China[82130111] ; Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000989230900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306542]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Dalian Med Univ, Coll Integrat Med, Coll Pharm, Dalian 116044, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, 501 Haike Rd, Shanghai 201203, Peoples R China 4.NMPA Key Lab Qual Control Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xin,Nie, Min,Wang, Mengyuan,et al. Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites[J]. FITOTERAPIA,2023,167:6. |
| APA | He, Xin.,Nie, Min.,Wang, Mengyuan.,Wu, Shifei.,Wei, Xuemei.,...&Guo, De-an.(2023).Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites.FITOTERAPIA,167,6. |
| MLA | He, Xin,et al."Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites".FITOTERAPIA 167(2023):6. |
入库方式： OAI收割
来源：上海药物研究所
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