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Smart drug delivery systems to overcome drug resistance in cancer immunotherapy

文献类型：期刊论文

作者Yi, Wenzhe2,3,4; Yan, Dan2,3,5; Wang, Dangge2,3,4,6; Li, Yaping1,2,3,4
刊名CANCER BIOLOGY & MEDICINE
出版日期2023-05-04
卷号20期号:4页码:248-267
ISSN号2095-3941
关键词Cancer immunotherapy drug resistance smart drug delivery system immunosuppressive microenvironment immune cell
DOI10.20892/j.issn.2095-3941.2023.0009
通讯作者Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Cancer immunotherapy, a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity, is currently an important clinical strategy for cancer treatment; however, tumors can develop drug resistance to immune surveillance, resulting in poor response rates and low therapeutic efficacy. In addition, changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic agents. Furthermore, tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell malfunction. To address these challenges, smart drug delivery systems (SDDSs) have been developed to overcome tumor cell resistance to immunomodulators, restore or boost immune cell activity, and magnify immune responses. To combat resistance to small molecules and monoclonal antibodies, SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells, thus increasing the drug concentration at the target site and improving efficacy. Herein, we discuss how SDDSs overcome drug resistance during cancer immunotherapy, with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive microenvironment. SDDSs that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also presented. Finally, we discuss potential future SDDS perspectives in overcoming drug resistance in cancer immunotherapy. We believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.
WOS关键词ADOPTIVE CELL TRANSFER ; TUMOR MICROENVIRONMENT ; T-CELLS ; CD47 BLOCKADE ; COMBINATION ; INTERFERON ; MECHANISMS ; THERAPY ; STRATEGIES ; EVOLUTION
资助项目National Key R&D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32170935] ; National Natural Science Foundation of China[31930066]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
出版者CHINA ANTI-CANCER ASSOC
WOS记录号WOS:000985262800001
源URL[http://119.78.100.183/handle/2S10ELR8/306545]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China
6.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
推荐引用方式
GB/T 7714		 Yi, Wenzhe,Yan, Dan,Wang, Dangge,et al. Smart drug delivery systems to overcome drug resistance in cancer immunotherapy[J]. CANCER BIOLOGY & MEDICINE,2023,20(4):248-267.
APA Yi, Wenzhe,Yan, Dan,Wang, Dangge,&Li, Yaping.(2023).Smart drug delivery systems to overcome drug resistance in cancer immunotherapy.CANCER BIOLOGY & MEDICINE,20(4),248-267.
MLA Yi, Wenzhe,et al."Smart drug delivery systems to overcome drug resistance in cancer immunotherapy".CANCER BIOLOGY & MEDICINE 20.4(2023):248-267.

入库方式： OAI收割

来源：上海药物研究所

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