Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer
文献类型：期刊论文
| 作者 | Zhao, Peng2,3,4,5; Qiu, Jianfei6; Pan, Chaolan2,3,4,5; Tang, Yunyan2,3,4,5; Chen, Meijun2,3,4,5; Song, Hui1,2,3; Yang, Jue2,3,4,5,7; Hao, Xiaojiang2,3,4,5 |
| 刊名 | PHYTOMEDICINE
 |
| 出版日期 | 2023-06-01 |
| 卷号 | 114页码:18 |
| ISSN号 | 0944-7113 |
| 关键词 | Curcumae Rhizoma Breast cancer Chemoresistance Metastasis Curcumin |
| DOI | 10.1016/j.phymed.2023.154810 |
| 通讯作者 | Song, Hui(songhui620@126.com) ; Yang, Jue(yaodadewo@163.com) ; Hao, Xiaojiang(haoxj2013@126.com) |
| 英文摘要 | Background: Breast cancer is the most prevalent cancer worldwide, with high morbidity and mortality. Despite great advances in the therapeutic strategies, the survival rate in the past decades of patients with breast cancer remains unsatisfactory. Growing evidence has demonstrated that Curcumae Rhizoma, called Ezhu in Chinese, showed various pharmacological properties, including anti-bacterial, anti-oxidant, anti-inflammatory and anti-tumor activities. It has been widely used in Chinese medicine to treat many types of human cancer. Purpose: To comprehensively summarize and analyze the effects of active substances in Curcumae Rhizoma on breast cancer malignant phenotypes and the underlying mechanisms, as well as discuss its medicinal value and future perspectives. Method: We used "Curcumae Rhizoma" or the name of crude extracts and bioactive components in Curcumae Rhizoma in combination with "breast cancer" as key words. Studies focusing on their anti-breast cancer activities and mechanisms of action were extracted from Pubmed, Web of Science and CNKI databases up to October 2022. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guideline was followed. Results: Crude extracts and 7 main bioactive phytochemicals (curcumol, beta-elemene, furanodiene, furanodienone, germacrone, curdione and curcumin) isolated from Curcumae Rhizoma have shown many anti-breast cancer pharmacological properties, including inhibiting cell proliferation, migration, invasion and stemness, reversing chemoresistance, and inducing cell apoptosis, cycle arrest and ferroptosis. The mechanisms of action were involved in regulating MAPK, PI3K/AKT and NF-kappa B signaling pathways. In vivo and clinical studies demonstrated that these compounds exhibited high anti-tumor efficacy and safety against breast cancer. Conclusion: These findings provide strong evidence that Curcumae Rhizoma acts as a rich source of phytochemicals and has robust anti-breast cancer properties. |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITION ; CELL-CYCLE ARREST ; ELEMENE REVERSES CHEMORESISTANCE ; BETA-ELEMENE ; ESSENTIAL OIL ; INHIBITS PROLIFERATION ; CHEMICAL-COMPOSITION ; SPARGANII-RHIZOMA ; NATURAL-PRODUCT ; MCF-7 CELLS |
| 资助项目 | National Natural Science Foundation of China[82160813] ; National Natural Science Foundation of China[32060210] ; National Natural Science Foundation of China[U1812403] ; State Key Laboratory of Drug Research[SIMM2105KF-15] ; Guizhou Provincial Natural Science and Technology Projects[QKHZK [2021] 526] ; Guizhou Provincial Natural Science and Technology Projects[QKHZK [2021] 448] ; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University[QJHKY [2020] 251] ; National Natural Science Foundation of China of Guizhou Medical University[20NSP064] ; National Natural Science Foundation of China of Guizhou Medical University[19NSP008] ; National Natural Science Foundation of China of Guizhou Medical University[Qian Ke He Ping Tai Ren Cai (2019])5106] ; National Natural Science Foundation of China of Guizhou Medical University[Tian-chanziJzi (2021)07] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| 出版者 | ELSEVIER GMBH |
| WOS记录号 | WOS:000985217500001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306566]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Song, Hui; Yang, Jue; Hao, Xiaojiang |
| 作者单位 | 1.Guizhou Med Univ, Key Lab Med Mol Biol Guizhou Prov, Guiyang, Peoples R China 2.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China 3.Guizhou Med Univ, Key Lab Endem & Ethn Dis, Minist Educ, Guiyang, Peoples R China 4.Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China 5.Chinese Acad Sci, Guiyang, Peoples R China 6.Guizhou Med Univ, Sch Basic Med, Key Lab Modern Pathogen Biol & Characterist, Guiyang, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Peng,Qiu, Jianfei,Pan, Chaolan,et al. Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer[J]. PHYTOMEDICINE,2023,114:18. |
| APA | Zhao, Peng.,Qiu, Jianfei.,Pan, Chaolan.,Tang, Yunyan.,Chen, Meijun.,...&Hao, Xiaojiang.(2023).Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer.PHYTOMEDICINE,114,18. |
| MLA | Zhao, Peng,et al."Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer".PHYTOMEDICINE 114(2023):18. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。