Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity
文献类型：期刊论文
| 作者 | Wang, Rongjing1; Zhang, Yuchao1; Guo, Shiwei2; Pei, Siyu3; Guo, Wei1; Wu, Zhenchuan1,4; Wang, Hailong1,5; Wang, Minghui1,4; Li, Yizhe1,4; Zhu, Yufei1 |
| 刊名 | ISCIENCE
 |
| 出版日期 | 2023-02-17 |
| 卷号 | 26期号:2页码:27 |
| DOI | 10.1016/j.isci.2023.105954 |
| 通讯作者 | Jin, Gang(jingang@smmu.edu.cn) ; Xiao, Yichuan(ycxiao@sibs.ac.cn) ; Hu, Landian(ldhu2013@163.com) ; Kong, Xiangyin(xykong@sibs.ac.cn) |
| 英文摘要 | Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is an important factor in the integrated stress response (ISR) in mammals and may play a crucial role in tumorigenesis. In our studies, we found an inhibitor of PPP1R15A, Sephin1, plays a protumorigenic role in mouse tumor models. By analyzing the single-cell transcriptome data of the mouse tumor models, we found that in C57BL/6 mice, Sephin1 treatment could lead to higher levels of ISR activity and lower levels of antitumor immune activities. Specifically, Sephin1 treatment caused reductions in antitumor immune cell types and lower expression levels of cytotoxicity-related genes. In addition, T cell receptor (TCR) repertoire analysis demonstrated that the clonal expansion of tumor-specific T cells was inhibited by Sephin1. A special TCR + macrophage subtype in tumor was identified to be significantly depleted upon Sephin1 treatment, implying its key antitumor role. These results suggest that PPP1R15A has the potential to be an effective target for tumor therapy. |
| WOS关键词 | ENDOPLASMIC-RETICULUM ; CANCER-IMMUNOTHERAPY ; MICROENVIRONMENTAL REGULATION ; TRANSLATIONAL CONTROL ; TUMOR PROGRESSION ; PROTEIN-SYNTHESIS ; GENE-EXPRESSION ; ALPHA-SUBUNIT ; GROWTH ARREST ; L-SELECTIN |
| 资助项目 | Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-STS-QYZD-187] ; National Key Research and Development Program of China[2017YFA0103501] ; Key Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC017] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000996401100001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306584]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jin, Gang; Xiao, Yichuan; Hu, Landian; Kong, Xiangyin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai, Peoples R China 2.Changhai Hosp, Dept Hepatobiliary Pancreat Surg, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ Sch Med SJTUSM, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, Dept Thorac Surg Oncol, Shanghai 200030, Peoples R China 4.Univ Chinese Acad Sci, Shanghai, Peoples R China 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai, Peoples R China 7.Anda Biol Med Dev Shenzhen Co Ltd, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rongjing,Zhang, Yuchao,Guo, Shiwei,et al. Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity[J]. ISCIENCE,2023,26(2):27. |
| APA | Wang, Rongjing.,Zhang, Yuchao.,Guo, Shiwei.,Pei, Siyu.,Guo, Wei.,...&Kong, Xiangyin.(2023).Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity.ISCIENCE,26(2),27. |
| MLA | Wang, Rongjing,et al."Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity".ISCIENCE 26.2(2023):27. |
入库方式： OAI收割
来源：上海药物研究所
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