Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica
文献类型：期刊论文
| 作者 | Li, Jin-Long4,5; Jiang, Jia-Yi4; Gu, Shan-Shan1; Zhang, Lei4; Sun, Yan1,3; Wang, Xue-Han5; Li, Dan-Yu5; Chen, Zhe-Yu4; Jiang, Sheng-Shi1; Zhu, Wei-Zhong4 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2023-05-27 |
| 页码 | 8 |
| ISSN号 | 1478-6419 |
| 关键词 | Pouzolzia zeylanica lignans ATP citrate lyase (ACLY) inhibitors |
| DOI | 10.1080/14786419.2023.2219816 |
| 通讯作者 | Li, Jin-Long(jinlongli@ntu.edu.cn) ; Jiang, Hao-Wen(Haowenjiang@simm.ac.cn) ; Zhang, Hong-Jie(zhanghj@hkbu.edu.hk) |
| 英文摘要 | A new lignan, named pouzolignan P (1), together with 14 known ones (2 - 15) were isolated from the roots of Pouzolzia zeylanica (L.) Benn. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates were evaluated for their inhibitory activities toward the ATP citrate lyase (ACLY). Among them, four lignans, isopouzolignan K (3), gnemontanins E (5), gnetuhainin I (6), and styraxlignolide D (15) showed excellent ACLY inhibitory effect with IC50 values of 9.06, 0.59, 2.63, and 7.62 mu M, respectively. These compounds were further evaluated for their cholesterol-lowing effects on ox-LDL-induced high-cholesterol HepG2 cells. Compound 15 emerges as the most potent ACLY inhibitor, which significantly decreased the TC level in a dose-dependent manner. In addition, molecular docking simulations elucidated that 15 formed a strong hydrogen-bond interaction with Glu599 of ACLY, which was an important site responsible for the enzyme catalytic activity. |
| 资助项目 | Hong Kong Scholars program[XJ2019054] ; Nantong Health Commission Project[MSZ2022022] ; Administration of Traditional Chinese Medicine of Jiangsu Province[YB201960] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:001000000300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306590]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Jin-Long; Jiang, Hao-Wen; Zhang, Hong-Jie |
| 作者单位 | 1.Nantong Hosp Tradit Chinese Med, Dept Pharm, Nantong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou, Peoples R China 4.Nantong Univ, Sch Pharm, Nantong, Peoples R China 5.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jin-Long,Jiang, Jia-Yi,Gu, Shan-Shan,et al. Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica[J]. NATURAL PRODUCT RESEARCH,2023:8. |
| APA | Li, Jin-Long.,Jiang, Jia-Yi.,Gu, Shan-Shan.,Zhang, Lei.,Sun, Yan.,...&Zhang, Hong-Jie.(2023).Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica.NATURAL PRODUCT RESEARCH,8. |
| MLA | Li, Jin-Long,et al."Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica".NATURAL PRODUCT RESEARCH (2023):8. |
入库方式： OAI收割
来源：上海药物研究所
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