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Resin glycosides from Merremia hederacea with multidrug-resistant reversal activities

文献类型：期刊论文

作者Li, Chen-Yue2,3; Fang, Jie1; Li, Guang-Yao1; Wang, Wen-Qiong2,4; Xuan, Li-Jiang2,4
刊名PHYTOCHEMISTRY LETTERS
出版日期2023-04-01
卷号54页码:14-17
ISSN号1874-3900
关键词Merremia hederacea Resin glycoside Multidrug-resistant reversal activity
DOI10.1016/j.phytol.2023.01.012
通讯作者Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn)
英文摘要To expand the resin glycoside composition of Merremia hederacea, aerial parts of M. hederacea were collected and investigated. Two previously undescribed resin glycosides, named merremins H-I were isolated from M. hederacea, and their structures were determined based on spectroscopic data and chemical evidence. The results suggested that merremins H-I had macrolactone structures, forming 18-membered rings. Merremins H-I were evaluated for their MDR reversal activities in KB/VCR cells by the SRB method. Merremin I showed moderate MDR reversal activity and increased the cytotoxicity of vincristine by 2.8-fold when incorporated at 25 mu M.
WOS关键词SEEDS
资助项目State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; Youth Innovation Promotion Association[2019284] ; Shanghai Municipal Science and Technology Major Project[TM202101H008]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000993502700001
源URL[http://119.78.100.183/handle/2S10ELR8/306593]  
专题新药研究国家重点实验室
通讯作者Wang, Wen-Qiong; Xuan, Li-Jiang
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210000, Peoples R China
2.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100000, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Chen-Yue,Fang, Jie,Li, Guang-Yao,et al. Resin glycosides from Merremia hederacea with multidrug-resistant reversal activities[J]. PHYTOCHEMISTRY LETTERS,2023,54:14-17.
APA Li, Chen-Yue,Fang, Jie,Li, Guang-Yao,Wang, Wen-Qiong,&Xuan, Li-Jiang.(2023).Resin glycosides from Merremia hederacea with multidrug-resistant reversal activities.PHYTOCHEMISTRY LETTERS,54,14-17.
MLA Li, Chen-Yue,et al."Resin glycosides from Merremia hederacea with multidrug-resistant reversal activities".PHYTOCHEMISTRY LETTERS 54(2023):14-17.

入库方式： OAI收割

来源：上海药物研究所

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