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Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice

文献类型：期刊论文

作者Li, Yu-Jie1; Du, Wei-Jia1; Liu, Rui1; Zan, Gui-Ying2; Ye, Bing-Lu1; Li, Qian1; Sheng, Zhi-Hao1; Yuan, Ya-Wei1; Song, Yu-Jie1; Liu, Jing-Gen2,4
刊名CNS NEUROSCIENCE & THERAPEUTICS
出版日期2023-05-29
页码14
ISSN号1755-5930
关键词anxiety central nucleus of the amygdala oxytocin pain paraventricular nucleus
DOI10.1111/cns.14282
通讯作者Liu, Jing-Gen(jgliu@simm.ac.cn) ; Liu, Zhi-Qiang(drliuzhiqiang@163.com)
英文摘要AimsAnxiety disorders associated with pain are a common health problem. However, the underlying mechanisms remain poorly understood. We aimed to investigate the role of paraventricular nucleus (PVN)-central nucleus of the amygdala (CeA) oxytocinergic projections in anxiety-like behaviors induced by inflammatory pain. MethodsAfter inflammatory pain induction by complete Freund's adjuvant (CFA), mice underwent elevated plus maze, light-dark transition test, and marble burying test to examine the anxiety-like behaviors. Chemogenetic, optogenetic, and fiber photometry recordings were used to modulate and record the activity of the oxytocinergic projections of the PVN-CeA. ResultsThe key results are as follows: inflammatory pain-induced anxiety-like behaviors in mice accompanied by decreased activity of PVN oxytocin neurons. Chemogenetic activation of PVN oxytocin neurons prevented pain-related anxiety-like behaviors, whereas inhibition of PVN oxytocin neurons induced anxiety-like behaviors in naive mice. PVN oxytocin neurons projected directly to the CeA, and microinjection of oxytocin into the CeA blocked anxiety-like behaviors. Inflammatory pain also decreased the activity of CeA neurons, and optogenetic activation of PVNoxytocin-CeA circuit prevented anxiety-like behavior in response to inflammatory pain. ConclusionThe results of our study suggest that oxytocin has anti-anxiety effects and provide novel insights into the role of PVNoxytocin-CeA projections in the regulation of anxiety-like behaviors induced by inflammatory pain.
WOS关键词CLINICALLY ANXIOUS YOUTH ; SEPARATION ANXIETY ; RECEPTOR ; STRESS ; PSYCHOPATHOLOGY ; ASSOCIATIONS
资助项目Pudong Health Committee of Shanghai[PW2021D-01] ; Clinical Research Plan of SHDC[SHDC22020205] ; Science and Technology Commission of Shanghai Municipality[19401930500] ; Natural Science Foundation of Shanghai[22ZR1449300] ; National Natural Science Foundation of China[81901376] ; National Natural Science Foundation of China[82001433]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:000997689600001
源URL[http://119.78.100.183/handle/2S10ELR8/306620]  
专题中国科学院上海药物研究所
通讯作者Liu, Jing-Gen; Liu, Zhi-Qiang
作者单位1.Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Inst Maternal Fetal Med & Gynecol Oncol, Clin & Translat Res Ctr,Dept Anesthesiol,Sch Med, Shanghai, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai, Peoples R China
3.Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Dept Anesthesiol, Shanghai 200092, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yu-Jie,Du, Wei-Jia,Liu, Rui,et al. Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice[J]. CNS NEUROSCIENCE & THERAPEUTICS,2023:14.
APA Li, Yu-Jie.,Du, Wei-Jia.,Liu, Rui.,Zan, Gui-Ying.,Ye, Bing-Lu.,...&Liu, Zhi-Qiang.(2023).Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice.CNS NEUROSCIENCE & THERAPEUTICS,14.
MLA Li, Yu-Jie,et al."Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice".CNS NEUROSCIENCE & THERAPEUTICS (2023):14.

入库方式： OAI收割

来源：上海药物研究所

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