Dual-Wavelength Comparative Imaging Based on a Novel NIR-II/IIb Emissive Rare Earth-Doped Nanoparticle
文献类型：期刊论文
| 作者 | Liu, Ruiqi1; Qiu, Yihua1; Wu, Fengxia1; Duan, Shuang1; Suo, Yongkuan1; Chang, Baisong5; Ren, Ying6; Tian, Mei4; Liu, Hongguang1; Cheng, Zhen2,3 |
| 刊名 | ADVANCED OPTICAL MATERIALS
 |
| 出版日期 | 2023-05-18 |
| 页码 | 12 |
| ISSN号 | 2195-1071 |
| 关键词 | multifunctional biomedical imaging NIR-II imaging NIR-IIb imaging RENPs |
| DOI | 10.1002/adom.202300378 |
| 通讯作者 | Tian, Mei(tianmei@fudan.edu.cn) ; Liu, Hongguang(simonliu@mail.neu.com.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | The second near-infrared biological window two (NIR-II, 1000-1700 nm) imaging has made remarkable achievements in fluorescence imaging of diseases. Here, this work takes advantage of the rich spectral properties of rare-earth doped nanoparticles (RENPs) and their capability to present multiple emission peaks in different luminescence regions simultaneously; novel RENPs are synthesized that have emission peaks in the NIR-II1000nm (1000-1300 nm) region and enhanced emission in the NIR-IIb (1500-1700 nm) window and are named as NEU-RENPs. These RENPs with new compositions enable a fair comparison to evaluate their imaging performance in NIR-II1000nm and NIR-IIb regions under the same conditions. The imaging abilities of the resulted nanoparticles in NIR-II1000 nm and NIR-IIb regions are investigated systematically for local blood vessels, tumor vessels, acute inflammatory vessels, arterial thrombosis, cerebrovascular inflammation, and brain injury models. The results indicate that imaging of NIR-IIb shows higher resolution and sensitivity than that of NIR-II1000nm, and it has a stronger ability to accurately distinguish normal and pathological tissues. Interestingly, the fuzzy image of NIR-II1000nm reveals more information about the background structure of the target, which is difficult to be achieved in NIR-IIb imaging. The results prove NEU-RENPs based NIR-IIb imaging is preferable for biomedical applications. |
| WOS关键词 | WINDOW |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[21?788?102] ; Key Laboratory of Bioresource Research and Development of Liaoning Province[2022JH13/10?200?026] |
| WOS研究方向 | Materials Science ; Optics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000990218800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306635]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tian, Mei; Liu, Hongguang; Cheng, Zhen |
| 作者单位 | 1.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, Shenyang 110000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Fudan Univ, Human Phenome Inst, Shanghai 201203, Peoples R China 5.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430000, Peoples R China 6.China Med Univ, Dept Radiol, Shengjing Hosp, Shenyang 110004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ruiqi,Qiu, Yihua,Wu, Fengxia,et al. Dual-Wavelength Comparative Imaging Based on a Novel NIR-II/IIb Emissive Rare Earth-Doped Nanoparticle[J]. ADVANCED OPTICAL MATERIALS,2023:12. |
| APA | Liu, Ruiqi.,Qiu, Yihua.,Wu, Fengxia.,Duan, Shuang.,Suo, Yongkuan.,...&Cheng, Zhen.(2023).Dual-Wavelength Comparative Imaging Based on a Novel NIR-II/IIb Emissive Rare Earth-Doped Nanoparticle.ADVANCED OPTICAL MATERIALS,12. |
| MLA | Liu, Ruiqi,et al."Dual-Wavelength Comparative Imaging Based on a Novel NIR-II/IIb Emissive Rare Earth-Doped Nanoparticle".ADVANCED OPTICAL MATERIALS (2023):12. |
入库方式： OAI收割
来源：上海药物研究所
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