Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins
文献类型：期刊论文
| 作者 | Chen, Xue-Bing1,2; Yao, Chang-Liang1; Hou, Jian-Ru1,2; Nie, Min1; Li, Yun1; Wei, Wen-Long1; Zhang, Jian-Qing1; Qu, Hua1; Li, Jia-Yuan1; Bi, Qi-Rui1 |
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2023-08-05 |
| 卷号 | 232页码:11 |
| ISSN号 | 0731-7085 |
| 关键词 | Gynostemma pentaphyllum Gypenosides Different origins Offline two-dimensional liquid separation sys tem Multimode data acquisition PIL data acquisition |
| DOI | 10.1016/j.jpba.2023.115328 |
| 通讯作者 | Guo, De-An(daguo@simm.ac.cn) |
| 英文摘要 | Gynostemma pentaphyllum (Thunb.) Makino is an herbaceous plant of Cucurbitaceae family, which has been widely used as an herbal tea and traditional Chinese medicine. Since its saponins are similar to ginsenosides and have a wide range of activities, it has attracted wide interest. However, there are still a large number of unknown saponins that have not been isolated, especially some trace gypenosides. In the present study, a HILIC x RP offline two-dimensional liquid separation combined with a multimode data acquisition was developed for the systematical characterization of gypenosides. On top of the negative mode information, considering that saponins are prone to in-source fragmentations in positive ion mode, a precursor ion list data acquisition method was used for the targeted acquisition of multistage positive data. Reference herbal drug was taken as a golden sample to probe the chemical composition of G. pentaphyllum. The mixed sample of commercially available samples were also analyzed in parallel. Furthermore, the chemical compositions of commercially available samples from different sources were compared. In total, 1108 saponins were characterized, among which 588 were accurately characterized, with 574 identified in the reference herbal drug and 700 in the mixed commercially available samples. The commercially available samples showed great composition variation. These findings clarified the material basis and provided clues for quality control of G. pentaphyllum. |
| WOS关键词 | MASS-SPECTROMETRY ; TIME ; IDENTIFICATION ; LC |
| 资助项目 | National Natural Science Foundation of China[82003938] ; National Natural Science Foundation of China[82130111] ; Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000998020900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306641]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-An |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharmaceut Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.NMPA Key Lab Qual Control Tradit Chinese Med, Shanghai 201203, Peoples R China 4.Shanghai Inst Mat Med, Chinese Acad Sci, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xue-Bing,Yao, Chang-Liang,Hou, Jian-Ru,et al. Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2023,232:11. |
| APA | Chen, Xue-Bing.,Yao, Chang-Liang.,Hou, Jian-Ru.,Nie, Min.,Li, Yun.,...&Guo, De-An.(2023).Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,232,11. |
| MLA | Chen, Xue-Bing,et al."Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 232(2023):11. |
入库方式： OAI收割
来源：上海药物研究所
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