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Chinese Academy of Sciences Institutional Repositories Grid
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  4. 新药研究国家重点实验室
The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity

文献类型：期刊论文

作者Yu, Shan1,2,3; Tang, Chunping1,2; Ke, Chang-Qiang1,2; Yao, Sheng1,2,3,4; Feng, Zheling1,2; Ye, Yang1,2,3,5
刊名FITOTERAPIA
出版日期2023-06-01
卷号167页码:9
关键词Artemisia nujianensis Guaianolide Artenujianolides A-H DFT NMR calculation Anti-inflammatory activity
ISSN号0367-326X
DOI10.1016/j.fitote.2023.105509
通讯作者Feng, Zheling() ; Ye, Yang(yye@simm.ac.cn)
英文摘要The first phytochemical investigation of Artemisia nujianensis resulted in the isolation of eight new guaianolides (1-8) and six known analogs. Their structures were determined by extensive analysis of 1D and 2D NMR data, HRESIMS data, DFT NMR calculations, and X-ray diffraction studies. Some compounds were evaluated for their anti-inflammatory activities in LPS-stimulated RAW 264.7 cells. Compounds 5, 7 and 9 showed moderate inhibitory effects on LPS-induced NO production in RAW 264.7 cells, with IC50 values of 12.50 +/- 0.21, 9.53 +/- 0.14 and 6.85 +/- 0.11 mu M, respectively.
WOS关键词SESQUITERPENE LACTONES
资助项目Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21920102003] ; Shanghai Pujiang Program[22PJD102] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000984342700001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/306644]  
专题新药研究国家重点实验室
通讯作者Feng, Zheling; Ye, Yang
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Shan,Tang, Chunping,Ke, Chang-Qiang,et al. The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity[J]. FITOTERAPIA,2023,167:9.
APA Yu, Shan,Tang, Chunping,Ke, Chang-Qiang,Yao, Sheng,Feng, Zheling,&Ye, Yang.(2023).The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity.FITOTERAPIA,167,9.
MLA Yu, Shan,et al."The first phytochemical investigation of Artemisia nujianensis: Eight new guaianolides and their anti-inflammatory activity".FITOTERAPIA 167(2023):9.

入库方式： OAI收割

来源：上海药物研究所

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