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Degradation of xylan by human gut Bacteroides xylanisolvens XB1A

文献类型：期刊论文

作者Zhao, Tingting1,2; Yue, Han2; Peng, Junfeng4; Nie, Yingmin2,3; Wu, Longzhen2; Li, Tingting2; Niu, Wei2; Li, Chuan2; Zhang, Zhengqing5; Li, Meixia2
刊名CARBOHYDRATE POLYMERS
出版日期2023-09-01
卷号315页码:10
ISSN号0144-8617
关键词Xylan Bacteroides xylanisolvens XB1A Dendrobium officinale Degradation
DOI10.1016/j.carbpol.2023.121005
通讯作者Zhang, Zhengqing(z_zhang@suda.edu.cn) ; Li, Meixia(limei@simm.ac.cn) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要Although many polysaccharides utilization loci (PULs) have been investigated by genomics and transcriptomics, the detailed functional characterization lags severely behind. We hypothesize that PULs on the genome of Bacteroides xylanisolvens XB1A (BX) dictate the degradation of complex xylan. To address, xylan S32 isolated from Dendrobium officinale was employed as a sample polysaccharide. We firstly showed that xylan S32 promoted the growth of BX which might degrade xylan S32 into monosaccharides and oligosaccharides. We further showed that this degradation was performed mainly via two discrete PULs in the genome of BX. Briefly, a new surface glycan binding protein (SGBP) BX_29290SGBP was identified, and shown to be essential for the growth of BX on xylan S32. Two cell surface endo-xylanases Xyn10A and Xyn10B cooperated to deconstruct the xylan S32. Intriguingly, genes encoding Xyn10A and Xyn10B were mainly distributed in the genome of Bacteroides spp. In addition, BX metabolized xylan S32 to produce short chain fatty acids (SCFAs) and folate. Taken together, these findings provide new evidence to understand the food source of BX and the BX-directed intervention strategy by xylan.
WOS关键词DENDROBIUM-OFFICINALE ; PREVOTELLA-BRYANTII ; SP-NOV. ; BACTERIUM ; METABOLISM ; MICROBIOTA ; DIVERSITY ; REVEALS ; STRAINS ; FIBERS
资助项目National Key R & D Program of China[2022YFA1303802] ; National Natural Science Foundation of China[31800673] ; National Natural Science Foundation of China[32271332] ; Shanghai Municipal Science and Technology Major Project ; High-level new R D institute[2019B090904008] ; High-level Innovative Research Institute from Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology
WOS研究方向Chemistry ; Polymer Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:001001527900001
源URL[http://119.78.100.183/handle/2S10ELR8/306662]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhengqing; Li, Meixia; Ding, Kan
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210029, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Naval Med Univ, Dept Pancreat Biliary Surg, Shanghai, Peoples R China
5.Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China
6.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Tingting,Yue, Han,Peng, Junfeng,et al. Degradation of xylan by human gut Bacteroides xylanisolvens XB1A[J]. CARBOHYDRATE POLYMERS,2023,315:10.
APA Zhao, Tingting.,Yue, Han.,Peng, Junfeng.,Nie, Yingmin.,Wu, Longzhen.,...&Ding, Kan.(2023).Degradation of xylan by human gut Bacteroides xylanisolvens XB1A.CARBOHYDRATE POLYMERS,315,10.
MLA Zhao, Tingting,et al."Degradation of xylan by human gut Bacteroides xylanisolvens XB1A".CARBOHYDRATE POLYMERS 315(2023):10.

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来源：上海药物研究所

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