Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification
文献类型：期刊论文
| 作者 | Wei, Qiang1,2; Wei, Wei1,2; Lai, Bo3; Wang, Lian-Yan1; Wang, Yu-Xia1; Su, Zhi-Guo1; Ma, Guang-Hui1 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2008-07-09 |
| 卷号 | 359期号:1-2页码:294-297 |
| 关键词 | PLA nanoparticles premix membrane emulsification uniform-sized |
| ISSN号 | 0378-5173 |
| 其他题名 | Int. J. Pharm. |
| 中文摘要 | Nanoparticle size is crucial to drug release behavior and biodistribution in vivo, but few studies have been performed on biodegradable nanoparticles with narrow size distribution. In this note, uniformsized nanoparticles were prepared by a facile method combining emulsion-solvent removal and premix membrane emulsification for the first time. After preparation of coarse emulsions, additional premix membrane emulsification with very high pressure was occupied to achieve uniform-sized nanodroplets, and nanoparticles were formed by further solidification. Polylactide (PLA) was selected as a model polymer. Several factors played key roles to obtain uniform-sized PLA nanoparticles, including type of organic solvent, the volume ratio of oil phase and external water phase, pore size of the microporous membrane and transmembrane pressure. The coefficient of variation (CV) value of PLA nanoparticles could be controlled below 16.9% under an optimum condition. The novel method also has the advantages of high productivity, simplicity and easy scale-up. The uniform-sized nanoparticles prepared by this novel method have great potentials in drug delivery. (C) 2008 Elsevier B.V. All rights reserved. |
| 英文摘要 | Nanoparticle size is crucial to drug release behavior and biodistribution in vivo, but few studies have been performed on biodegradable nanoparticles with narrow size distribution. In this note, uniformsized nanoparticles were prepared by a facile method combining emulsion-solvent removal and premix membrane emulsification for the first time. After preparation of coarse emulsions, additional premix membrane emulsification with very high pressure was occupied to achieve uniform-sized nanodroplets, and nanoparticles were formed by further solidification. Polylactide (PLA) was selected as a model polymer. Several factors played key roles to obtain uniform-sized PLA nanoparticles, including type of organic solvent, the volume ratio of oil phase and external water phase, pore size of the microporous membrane and transmembrane pressure. The coefficient of variation (CV) value of PLA nanoparticles could be controlled below 16.9% under an optimum condition. The novel method also has the advantages of high productivity, simplicity and easy scale-up. The uniform-sized nanoparticles prepared by this novel method have great potentials in drug delivery. (C) 2008 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | DRUG-DELIVERY ; PROTEIN DRUG ; NANOCARRIERS ; FORMULATION ; PARTICLES ; CHITOSAN ; SOLVENT |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000257530400038 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2880]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Beijing Univ Sci & Technol, Dept Biochem Engn, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Qiang,Wei, Wei,Lai, Bo,et al. Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,359(1-2):294-297. |
| APA | Wei, Qiang.,Wei, Wei.,Lai, Bo.,Wang, Lian-Yan.,Wang, Yu-Xia.,...&Ma, Guang-Hui.(2008).Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification.INTERNATIONAL JOURNAL OF PHARMACEUTICS,359(1-2),294-297. |
| MLA | Wei, Qiang,et al."Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification".INTERNATIONAL JOURNAL OF PHARMACEUTICS 359.1-2(2008):294-297. |
入库方式： OAI收割
来源：过程工程研究所
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