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Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri

文献类型：期刊论文

作者Yu, Jia-Dong1,2,3; Su, Ming-Zhi4; Gu, Yu-Cheng5; Yu, Dan-Dan4; Yao, Li-Gong3; Shen, Shou-Mao3; Guo, Yue-Wei1,2,3,4,6; Wang, Hong1,2
刊名CHEMISTRY & BIODIVERSITY
出版日期2023-06-09
页码7
ISSN号1612-1872
关键词soft coral Sarcophyton boettgeri cembranoids stereochemistry biological activities
DOI10.1002/cbdv.202300662
通讯作者Shen, Shou-Mao(joint-shenshoumao@simm.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) ; Wang, Hong(hongw@zjut.edu.cn)
英文摘要Two new cembranoids, namely sarcoboettgerols D and E, together with four known related ones, have been isolated from the soft coral Sarcophyton boettgeri collected from Weizhou Island in the South China Sea. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance methods, time-dependent density functional theory-electronic circular dichroism calculations, as well as comparison with the reported data in the literature. A plausible biogenetic relationship of four cembranoids was proposed. In bioassays, sarcomililatin B exhibited cytotoxic activity against H1299 cell (IC50=35.0 mu M), whereas sarcomililatin B and sarcomililatin A displayed moderate antibacterial activities (MIC 17.4-34.8 mu g/mL).
资助项目National Key Research and Development Program of China[2022YFC2804100] ; National Natural Science Foundation of China[81991521]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:001003391200001
源URL[http://119.78.100.183/handle/2S10ELR8/306683]  
专题新药研究国家重点实验室
通讯作者Shen, Shou-Mao; Guo, Yue-Wei; Wang, Hong
作者单位1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.Bohai rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
5.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
6.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Jia-Dong,Su, Ming-Zhi,Gu, Yu-Cheng,et al. Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri[J]. CHEMISTRY & BIODIVERSITY,2023:7.
APA Yu, Jia-Dong.,Su, Ming-Zhi.,Gu, Yu-Cheng.,Yu, Dan-Dan.,Yao, Li-Gong.,...&Wang, Hong.(2023).Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri.CHEMISTRY & BIODIVERSITY,7.
MLA Yu, Jia-Dong,et al."Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri".CHEMISTRY & BIODIVERSITY (2023):7.

入库方式： OAI收割

来源：上海药物研究所

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