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Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence

文献类型：期刊论文

作者Liu, Yu-Wen1; Wang, Meng-Meng2; Zhang, Yun-Qian1; Xu, Hui1; Dai, Hui-Xiong1,2,3
刊名ORGANIC LETTERS
出版日期2023-07-17
卷号25期号:29页码:5406-5410
ISSN号1523-7060
DOI10.1021/acs.orglett.3c01579
通讯作者Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要Herein, we report the transformation of aromatic acidsto indole-fusedseven- and eight-membered azaheterocycles. Two C-C bonds areformed via the cleavage of one C-C bond and two C-Hbonds. The incorporation of indole moieties into bioactive pharmaceuticalsand natural products to construct a medium-sized polyfused heterocycledemonstrates the synthetic utility of the protocol.
WOS关键词ARYL IODIDES ; REGIOSELECTIVE SYNTHESIS ; PALLADIUM ; NORBORNENE ; THIOESTERS ; ROUTE ; FUNCTIONALIZATION ; ALKYLATION
资助项目Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[22171276] ; National Natural Science Foundation of China[21920102003] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science amp; Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001030479800001
源URL[http://119.78.100.183/handle/2S10ELR8/306707]  
专题新药研究国家重点实验室
通讯作者Xu, Hui; Dai, Hui-Xiong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yu-Wen,Wang, Meng-Meng,Zhang, Yun-Qian,et al. Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence[J]. ORGANIC LETTERS,2023,25(29):5406-5410.
APA Liu, Yu-Wen,Wang, Meng-Meng,Zhang, Yun-Qian,Xu, Hui,&Dai, Hui-Xiong.(2023).Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence.ORGANIC LETTERS,25(29),5406-5410.
MLA Liu, Yu-Wen,et al."Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence".ORGANIC LETTERS 25.29(2023):5406-5410.

入库方式： OAI收割

来源：上海药物研究所

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