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Enhancing the oral bioavailability of poorly water-soluble amisupiride with solid nanodispersion

文献类型：期刊论文

作者Zhang, Xinyue1,2; Li, Jie1,2; Rong, Rong3; Wang, Dangge1,2; Wang, Donghai4; Yu, Yanling4; Wu, Pei4; Li, Yaping1,2,5; Zhang, Zhiwen1,2,3
刊名JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
出版日期2023-09-01
卷号86页码:6
关键词Solid dispersion Oral bioavailability Amisupiride Nanoparticle Poorly water-soluble drugs
ISSN号1773-2247
DOI10.1016/j.jddst.2023.104635
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fuan.edu.cn)
英文摘要The limited oral bioavailability remains an essential challenge of poorly water-soluble amisupride (AMS). Herein, we designed a solid nanodispersion system of AMS (AMS-SN) by dispersing AMS into a polymeric matrix composed of Solutol HS-15, polyvinylpolypyrrolidone (PVPP), and poly (maleic anhydride-alt-1-octadecene) (PMHC18) to improve the oral bioavailability of AMS. AMS existed in the AMS-SN system in amorphous or molecular state. Moreover, AMS-SN could transform into nanometer-sized particles upon their exposure in the gastrointestinal fluids. Compared to the AMS suspension, the absorption of AMS in the duodenum, jejunum and ileum increased significantly by 8.02, 32.18 and 9.11-fold by the AMS-SN formulation, respectively. Particularly, the AMS-SN system produced an 8.58-fold enhancement of oral bioavailability of AMS. Therefore, solid nanodispersion provides a feasible pharmaceutical platform for oral delivery of poorly water-soluble drugs (PWSDs).
WOS关键词SELF-ASSEMBLED NANOPARTICLES ; DELIVERY-SYSTEM ; BREAST-CANCER ; AMISULPRIDE ; DISPERSIONS ; CHALLENGES ; STRATEGIES ; MICELLES
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001027356000001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/306710]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Zhiwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
4.Qilu Pharmaceut Co Ltd, Jinan 250100, Shandong, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xinyue,Li, Jie,Rong, Rong,et al. Enhancing the oral bioavailability of poorly water-soluble amisupiride with solid nanodispersion[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2023,86:6.
APA Zhang, Xinyue.,Li, Jie.,Rong, Rong.,Wang, Dangge.,Wang, Donghai.,...&Zhang, Zhiwen.(2023).Enhancing the oral bioavailability of poorly water-soluble amisupiride with solid nanodispersion.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,86,6.
MLA Zhang, Xinyue,et al."Enhancing the oral bioavailability of poorly water-soluble amisupiride with solid nanodispersion".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 86(2023):6.

入库方式： OAI收割

来源：上海药物研究所

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