A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases
文献类型：期刊论文
| 作者 | Cao, Yinghao1; Lin, Yexuan1; Sun, Na1; Du, Xinyi1; Dong, Yixin1; Mei, Song1; Deng, Xingyu1; Li, Xiaobei1; Guo, Shaoting1; Tang, Kegong1 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2023-06-26 |
| 页码 | 19 |
| ISSN号 | 1674-7305 |
| 关键词 | small RNA herbal decoction cross-kingdom regulation traditional Chinese medicine RNA oligonucleotide drug RNA therapeutics Bencao small RNA Atlas |
| DOI | 10.1007/s11427-022-2181-6 |
| 通讯作者 | Huang, Fengming(hfmyykejian@163.com) ; Wang, Xiaoyue(wxy@ibms.pumc.edu.cn) ; Jiang, Chengyu(jiang@pumc.edu.cn) |
| 英文摘要 | Cross-kingdom herbal miRNA was first reported in 2012. Using a modified herbal extraction protocol, we obtained 73,677,287 sequences by RNA-seq from 245 traditional Chinese Medicine (TCM), of which 20,758,257 were unique sequences. We constructed a Bencao (herbal) small RNA (sRNA) Atlas (http://bencao.bmicc.cn/), annotated the sequences by sequence-based clustering, and created a nomenclature system for Bencao sRNAs. The profiles of 21,757 miRNAs in the Atlas were highly consistent with those of plant miRNAs in miRBase. Using software tools, our results demonstrated that all human genes might be regulated by sRNAs from the Bencao sRNA Atlas, part of the predicted human target genes were experimentally validated, suggesting that Bencao sRNAs might be one of the main bioactive components of herbal medicines. We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions. Moreover, the decoctosome, a lipo-nano particle consisting of 0.5%-2.5% of the decoction, demonstrated potent medical effects. We propose a Bencao (herbal) Index, including small-molecule compounds (SM), protein peptides (P), nucleic acid (N), non-nucleic and non-proteinogenic large-molecule compounds (LM) and elements from Mendeleev's periodic table (E), to quantitatively measure the medical effects of botanic medicine. The Bencao sRNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine, and may provide potential remedies for the theory and practice of one medicine. |
| WOS关键词 | PLANT ; GROWTH ; IDENTIFICATION ; METHYLATION ; PREDICTION ; MICRORNAS ; TARGETS |
| 资助项目 | National Natural Science Foundation of China[81788101] ; National Natural Science Foundation of China[32100104] ; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[2021-I2M-1-022] ; CAMS Endowment Fund[2021-CAMS-JZ001] ; Overseas Expertise Introduction Center for Discipline Innovation (111 Center)[BP0820029] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:001022088400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306713]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Fengming; Wang, Xiaoyue; Jiang, Chengyu |
| 作者单位 | 1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Sch Basic Med, Dept Biochem, Beijing 100005, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Engn Res Ctr Chinese Med Resource Minist Educ, Key Lab Chinese Med Resources Conservat, Beijing 100193, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Tradit Chinese Med, Beijing 100005, Peoples R China 4.Univ Sci & Technol China, Sch Life Sci, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Peoples R China 5.Univ Oxford, MRC Weatherall Inst Mol Med, Radcliffe Dept Med, MRC Human Immunol Unit, Oxford OX3 7FZ, England 6.Univ Oxford, Chinese Acad Med Sci CAMS, CAMS Oxford Inst COI, Nuffield Dept Med, Oxford OX3 7FZ, England 7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China 8.Univ Oxford, Target Discovery Inst, Ctr Med Discovery, Nuffield Dept Med, Oxford OX3 7FZ, England 9.Univ Missouri, Dept Elect Engn & Comp Sci, Columbia, MO 65211 USA 10.Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA |
| 推荐引用方式 GB/T 7714 | Cao, Yinghao,Lin, Yexuan,Sun, Na,et al. A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases[J]. SCIENCE CHINA-LIFE SCIENCES,2023:19. |
| APA | Cao, Yinghao.,Lin, Yexuan.,Sun, Na.,Du, Xinyi.,Dong, Yixin.,...&Jiang, Chengyu.(2023).A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases.SCIENCE CHINA-LIFE SCIENCES,19. |
| MLA | Cao, Yinghao,et al."A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases".SCIENCE CHINA-LIFE SCIENCES (2023):19. |
入库方式： OAI收割
来源：上海药物研究所
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