Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides
文献类型：期刊论文
| 作者 | Li, Song-Wei1,2; Liu, Jiao3; Fu, Yan3; Yao, Li-Gong3; Zhang, Hai-Yan3 ; Wang, Hong1,2; Guo, Yue-Wei1,2,3,4
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023-07-06 |
| 页码 | 5 |
| ISSN号 | 1612-1872 |
| 关键词 | Anti-inflammatory activity Lobophytum sarcophytoides Soft coral Steroids Structure elucidation |
| DOI | 10.1002/cbdv.202300821 |
| 通讯作者 | Wang, Hong(hongw@zjut.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Three new steroids, along with two known related analogs, were isolated from the Xisha Island soft coral Lobophytum sarcophytoides. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic data analyses, time dependent density functional theory electronic circular dichroism calculation, and comparison with the spectral data previously reported in the literature. In in vitro bioassay, four compounds showed interesting suppressive effects on lipopolysaccharide (LPS) induced inflammation in BV-2 microglial cells at 10 mu M level. |
| WOS关键词 | CEMBRANOID DITERPENE |
| 资助项目 | National Key Research and Development Program of China[2022YFC2804100] ; National Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:001019975800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306716]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310014, Peoples R China 2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, 18 Chaowang Rd, Hangzhou 310014, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Song-Wei,Liu, Jiao,Fu, Yan,et al. Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides[J]. CHEMISTRY & BIODIVERSITY,2023:5. |
| APA | Li, Song-Wei.,Liu, Jiao.,Fu, Yan.,Yao, Li-Gong.,Zhang, Hai-Yan.,...&Guo, Yue-Wei.(2023).Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides.CHEMISTRY & BIODIVERSITY,5. |
| MLA | Li, Song-Wei,et al."Anti-Inflammatory Steroids from the South China Sea Soft Coral Lobophytum sarcophytoides".CHEMISTRY & BIODIVERSITY (2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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