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Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier
文献类型：期刊论文
| 作者 | Wei, Wei1; Ma, Guang-Hui1; Hu, Gang2; Yu, Di3; Mcleish, Tom4; Su, Zhi-Guo1; Shen, Zhe-Yu1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2008-11-26 |
| 卷号 | 130期号:47页码:15808-+ |
| 关键词 | calcium-carbonate nanoparticles induced self-transformation microspheres delivery microparticles resistance micelles efficacy protein uniform |
| ISSN号 | 0002-7863 |
| 其他题名 | J. Am. Chem. Soc. |
| 中文摘要 | One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry. |
| 英文摘要 | One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CALCIUM-CARBONATE NANOPARTICLES ; INDUCED SELF-TRANSFORMATION ; MICROSPHERES ; DELIVERY ; MICROPARTICLES ; RESISTANCE ; MICELLES ; EFFICACY ; PROTEIN ; UNIFORM |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000263319600032 |
| 公开日期 | 2013-10-08 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/2882]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 2.Unilever Res China, Shanghai 200233, Peoples R China 3.Garvan Inst Med Res, Sydney, NSW 2010, Australia 4.Univ Leeds, Sch Phys & Astron, Leeds LS2 9JT, W Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Ma, Guang-Hui,Hu, Gang,et al. Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2008,130(47):15808-+. |
| APA | Wei, Wei.,Ma, Guang-Hui.,Hu, Gang.,Yu, Di.,Mcleish, Tom.,...&Shen, Zhe-Yu.(2008).Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,130(47),15808-+. |
| MLA | Wei, Wei,et al."Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130.47(2008):15808-+. |
入库方式： OAI收割
来源：过程工程研究所
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