Highly Modified Sesquiterpene Lactones with Cytotoxic Activities from Strobocalyx chunii
文献类型：期刊论文
| 作者 | Ge, Zhan-Peng1; Gao, Yuan1; Zhang, Yan1; Liu, Hong-Chun1 ; Zhao, Jin-Xin1,2; Yue, Jian-Min1,2,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2023-07-20 |
| 卷号 | 88期号:15页码:11122-11129 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.3c01104 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Three new germacranolide sesquiterpenelactones (SLs),strochunolidesA-C (1-3, respectively), anda new guaianolide SL, strochunolide D (4), were isolatedfrom Strobocalyx chunii and structurally characterized.Compound 1 is the first example of a dihomo-germacranolideSL, characterized by an unprecedented 6/10/5 tricyclic scaffold incorporatingan additional fused & delta;-lactone C-ring. The structure of a knowngermacranolide SL, spicatolide C (5), was revised asits 8-epimer. Compound 3 exhibited potent invitro cytotoxic activity against the HL-60 cell line, withan IC50 value of 0.18 & PLUSMN; 0.01 & mu;M. |
| WOS关键词 | ZALUZANIN-D ; ANTICANCER |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; Youth Innovation Promotion Association of CAS[2022282] ; Youth Innovation Promotion Association of CAS[2023293] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Biological Resources Program of Chinese Academy of Sciences[KFJ-BRP-008-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:001033042200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306737]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shandong Lab Yantai Drug Discovery, Bohai Rim Adv Res Inst Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Zhan-Peng,Gao, Yuan,Zhang, Yan,et al. Highly Modified Sesquiterpene Lactones with Cytotoxic Activities from Strobocalyx chunii[J]. JOURNAL OF ORGANIC CHEMISTRY,2023,88(15):11122-11129. |
| APA | Ge, Zhan-Peng,Gao, Yuan,Zhang, Yan,Liu, Hong-Chun,Zhao, Jin-Xin,&Yue, Jian-Min.(2023).Highly Modified Sesquiterpene Lactones with Cytotoxic Activities from Strobocalyx chunii.JOURNAL OF ORGANIC CHEMISTRY,88(15),11122-11129. |
| MLA | Ge, Zhan-Peng,et al."Highly Modified Sesquiterpene Lactones with Cytotoxic Activities from Strobocalyx chunii".JOURNAL OF ORGANIC CHEMISTRY 88.15(2023):11122-11129. |
入库方式： OAI收割
来源：上海药物研究所
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