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Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors

文献类型：期刊论文

作者Ye, Binglu1; Yuan, Yawei1; Liu, Rui1; Zhou, Haitao3,4,5; Li, Yujie1; Sheng, Zhihao1; Li, Tianyu1,3,4; Zhang, Bing1,2; Xu, Zhendong1,2; Li, Yang3,4,5,6
刊名MOLECULAR MEDICINE
出版日期2023-07-25
卷号29期号:1页码:18
ISSN号1076-1551
关键词Postpartum depression (PPD) Neurotransmission Hippocampus CA1 Wnt signaling
DOI10.1186/s10020-023-00697-4
通讯作者Xu, Zhendong(btxzd123@126.com) ; Li, Yang(liyang@simm.ac.cn) ; Liu, Zhiqiang(drliuzhiqiang@163.com)
英文摘要BackgroundPostpartum depression (PPD) is a prevalent mental disorder that negatively impacts mothers and infants. The mechanisms of vulnerability to affective illness in the postpartum period remain largely unknown. Drastic fluctuations in reproductive hormones during the perinatal period generally account for triggering PPD. However, the molecular mechanism underlying the PPD-like behaviors induced by the fluctuations in hormones has rarely been reported.MethodsWe utilized hormones-simulated pseudopregnancy (HSP) and hormones-simulated postpartum period (HSPP) rat models to determine how drastic fluctuations in hormone levels affect adult neurotransmission and contribute to depressive-like behaviors. The electrophysiological response of CA1 pyramidal neurons was evaluated by whole-cell patch clamping to identify the hormone-induced modulations of neurotransmission. The statistical significance of differences was assessed with One-way ANOVA and t-test (p < 0.05 was considered significant).ResultsReproductive hormones withdrawal induced depressive-like behaviors and disturbed the balance of excitatory and inhibitory transmission in the pyramidal neurons in the hippocampus. Molecular analyses revealed that the blunted Wnt signaling might be responsible for the deficits of synaptic transmission and behaviors. Activation of Wnt signaling increased excitatory and inhibitory synaptic transmission in the hippocampus. Reactivation of Wnt signaling alleviated the anhedonic behaviors and abnormal synaptic transmission.ConclusionsRestoring Wnt signaling in the hormones-simulated postpartum period rat models remediated depression-related anhedonia symptoms and rebalanced the excitation/inhibition ratio by collectively enhancing the plasticity of GABAergic and glutamatergic synapses. The investigations carried out in this research might provide an alternative and prospective treatment strategy for PPD.
WOS关键词HIPPOCAMPAL NEUROGENESIS ; MATERNAL BRAIN ; PLASTICITY ; RAT ; MODULATION ; PREGNANCY ; DISORDER ; HISTORY ; NEURONS
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine
语种英语
出版者SPRINGER
WOS记录号WOS:001033030500001
源URL[http://119.78.100.183/handle/2S10ELR8/306743]  
专题新药研究国家重点实验室
通讯作者Xu, Zhendong; Li, Yang; Liu, Zhiqiang
作者单位1.Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Dept Anesthesiol, Shanghai 201204, Peoples R China
2.Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Inst Maternal Fetal Med & Gynecol Oncol, Clin & Translat Res Ctr,Sch Med,Shanghai Key Lab, Shanghai 201204, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, 9A Yuquan Rd, Beijing 100049, Peoples R China
6.Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai 200040, Peoples R China
推荐引用方式
GB/T 7714		 Ye, Binglu,Yuan, Yawei,Liu, Rui,et al. Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors[J]. MOLECULAR MEDICINE,2023,29(1):18.
APA Ye, Binglu.,Yuan, Yawei.,Liu, Rui.,Zhou, Haitao.,Li, Yujie.,...&Liu, Zhiqiang.(2023).Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors.MOLECULAR MEDICINE,29(1),18.
MLA Ye, Binglu,et al."Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors".MOLECULAR MEDICINE 29.1(2023):18.

入库方式： OAI收割

来源：上海药物研究所

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