Structural insights into the evolutionary simplification of human ClpP activators
文献类型：期刊论文
| 作者 | Zhou, Lin -Lin1,2,3; Yang, Cai-Guang1,2,3
|
| 刊名 | STRUCTURE
 |
| 出版日期 | 2023-02-02 |
| 卷号 | 31期号:2页码:125-127 |
| ISSN号 | 0969-2126 |
| DOI | 10.1016/j.str.2023.01.002 |
| 通讯作者 | Yang, Cai-Guang(yangcg@simm.ac.cn) |
| 英文摘要 | In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201. These novel compounds are of potential therapeutic interest because they enhance ClpP proteolytic activity and have an inhibitory effect on tumor cell growth. |
| 资助项目 | National Natural Science Foundation of China[22037007] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:001028365200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306755]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Cai-Guang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Chem Biol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lin -Lin,Yang, Cai-Guang. Structural insights into the evolutionary simplification of human ClpP activators[J]. STRUCTURE,2023,31(2):125-127. |
| APA | Zhou, Lin -Lin,&Yang, Cai-Guang.(2023).Structural insights into the evolutionary simplification of human ClpP activators.STRUCTURE,31(2),125-127. |
| MLA | Zhou, Lin -Lin,et al."Structural insights into the evolutionary simplification of human ClpP activators".STRUCTURE 31.2(2023):125-127. |
入库方式： OAI收割
来源：上海药物研究所
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