中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study

文献类型：期刊论文

作者Xu, Baohua1,2; Yang, Ting3; Zhou, Jianxing1,2; Zheng, You1,2; Wang, Jingting4; Liu, Qingxia1,2; Li, Dandan1,2; Zhang, Yifan5; Liu, Maobai1,6; Wu, Xuemei1,6
刊名CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
出版日期2023-07-25
页码12
ISSN号2163-8306
DOI10.1002/psp4.13004
通讯作者Liu, Maobai(liumb0591@fjmu.edu.cn) ; Wu, Xuemei(wuxuemei@fjmu.edu.cn)
英文摘要Therapeutic drug monitoring (TDM) of busulfan (BU) is currently performed by plasma sampling in patients undergoing hematopoietic stem cell transplantation (HSCT). Saliva samples are considered a noninvasive TDM matrix. Currently, no salivary population pharmacokinetics (PopPKs) model for BU available. This study aimed to develop a PopPK model that can describe the relationship between plasma and saliva kinetics in patients receiving intravenous BU. The performance of the model in predicting the area under the concentration-time curve at steady state (AUC(ss)) based on saliva samples is evaluated. Sixty-six patients with HSCT were recruited and administered 0.8 mg/kg BU intravenously. A PopPK model for saliva and plasma was developed using the nonlinear mixed effects model. Bayesian maximum a posteriori (MAP) optimization was used to estimate the model's predictive performance. Plasma and saliva PKs were adequately described with a one-compartment model and a scaled central compartment. Body surface area correlated positively with both clearance and apparent volume of distribution (Vd), whereas alkaline phosphatase correlated negatively with Vd. Simulations demonstrated that the percentage root mean squared prediction error and lower and upper limits of agreements reduced to 10.02% and -16.96% to 22.86% based on five saliva samples. Saliva can be used as an alternative matrix to plasma in TDM of BU. The AUC(ss) can be predicted from saliva concentration by Bayesian MAP optimization, which can be used to design personalized dosing for BU.
WOS关键词MARROW TRANSPLANTATION ; VENOOCCLUSIVE DISEASE ; ORAL BUSULFAN ; ADULT PATIENTS ; CYCLOPHOSPHAMIDE ; PLASMA ; BLOOD ; SERUM ; QUANTIFICATION ; FLUDARABINE
资助项目Joint Funds for the innovation of Science and Technology, Fujian Province (China)[2019Y9059]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:001036392100001
源URL[http://119.78.100.183/handle/2S10ELR8/306761]  
专题中国科学院上海药物研究所
通讯作者Liu, Maobai; Wu, Xuemei
作者单位1.Fujian Med Univ, Dept Pharm, Union Hosp, Fuzhou, Fujian, Peoples R China
2.Fujian Med Univ, Sch Pharm, Fuzhou, Fujian, Peoples R China
3.Fujian Med Univ, Dept Hematol, Union Hosp, Fuzhou, Fujian, Peoples R China
4.Univ Michigan, Coll Pharm, Ann Arbor, MI USA
5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
6.Fujian Med Univ, Dept Pharm, Union Hosp, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Baohua,Yang, Ting,Zhou, Jianxing,et al. Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study[J]. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY,2023:12.
APA Xu, Baohua.,Yang, Ting.,Zhou, Jianxing.,Zheng, You.,Wang, Jingting.,...&Wu, Xuemei.(2023).Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study.CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY,12.
MLA Xu, Baohua,et al."Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study".CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2023):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。