Mitochondria-Targeting Small-Molecule NIR-II Fluorescent Probes for Imaging and Treatment of Tumor
文献类型：期刊论文
| 作者 | Li, Mingxun1,2; Wu, Yibin1,2; He, Chunfeng2,3; Li, Xinxin2,5; Tao, Ji2; Qu, Chunrong2; Chen, Wen-Hua1; Cheng, Zhen2,3,4 |
| 刊名 | ADVANCED THERAPEUTICS
 |
| 出版日期 | 2023-07-24 |
| 页码 | 10 |
| 关键词 | mitochondrial membrane potential NIR-II imaging photothermal therapy small molecule probes tumors |
| DOI | 10.1002/adtp.202300151 |
| 通讯作者 | Qu, Chunrong(crqu@simm.ac.cn) ; Chen, Wen-Hua(whchen@wyu.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Mitochondrial membrane potential (& UDelta;& psi;m)-targeting molecular probes play an essential role in diagnosing and treating diseases. Recently, the second near-infrared window (NIR-II, 1000-1700 nm) fluorescent imaging has been actively studied as an attractive imaging modality. However, small molecule & UDelta;& psi;m-targeting NIR-II probes are rarely reported, especially for highly efficient imaging and treatment of tumors. Herein, a small molecule probe named TQPTPP is designed and synthesized by conjugation of a novel D-A type dye TQT1009 with & UDelta;& psi;m-targeting molecule alkyl triphenylphosphine (TPP) through a polyethylene glycol-8 (PEG(8)) linker. The conventional ICG dye is also coupled with TPP through PEG(8) to produce ICGTPP as a comparison. TQPTPP showed a fluorescence quantum yield of 0.041% and excellent photothermal conversion efficiency (61.4%). It can be self-assembled into nanoparticles and still preserve & UDelta;& psi;m-targeting capability. Tumor imaging is further performed, and results showed a long tumor retention time of TQPTPP (maximum tumor signal on day five and signal-to-noise ratio up to nine). As a comparison, ICGTPP remained a single molecule with & UDelta;& psi;m-targeting capability. But it has shorter tumor retention and lower photostability. These results suggested the novel D-A small molecule & UDelta;& psi;m-targeting NIR-II probe TQPTPP provided a new tool for diagnosing and treating tumors. |
| WOS关键词 | FLUOROPHORES ; DELIVERY ; THERAPY ; DYE |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[81901799] ; Chinese Academy of Sciences |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:001032188600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306770]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qu, Chunrong; Chen, Wen-Hua; Cheng, Zhen |
| 作者单位 | 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 5.First Hosp Jilin Univ, Dept Radiol, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mingxun,Wu, Yibin,He, Chunfeng,et al. Mitochondria-Targeting Small-Molecule NIR-II Fluorescent Probes for Imaging and Treatment of Tumor[J]. ADVANCED THERAPEUTICS,2023:10. |
| APA | Li, Mingxun.,Wu, Yibin.,He, Chunfeng.,Li, Xinxin.,Tao, Ji.,...&Cheng, Zhen.(2023).Mitochondria-Targeting Small-Molecule NIR-II Fluorescent Probes for Imaging and Treatment of Tumor.ADVANCED THERAPEUTICS,10. |
| MLA | Li, Mingxun,et al."Mitochondria-Targeting Small-Molecule NIR-II Fluorescent Probes for Imaging and Treatment of Tumor".ADVANCED THERAPEUTICS (2023):10. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。