Spectral and biodistributional engineering of deep near-infrared chromophore
文献类型：期刊论文
| 作者 | Dong, Yan1; Lu, Xicun1; Li, Yi1; Chen, Weichao1; Yin, Lei1; Zhao, Jie1; Hu, Xinru1; Li, Xinran1; Lei, Zuhai1; Wu, Yuyang3 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2023-09-01 |
| 卷号 | 34期号:9页码:7 |
| 关键词 | Near infrared fluorophore In vivo imaging Molecular engineering Biological distribution Angiography |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2023.108154 |
| 通讯作者 | Yang, Youjun(youjunyang@ecust.edu.cn) |
| 英文摘要 | Fluorescence-guided surgery calls for development of near-infrared fluorophores. Despite the wide-spread application and a safe clinical record of Indocyanine Green (ICG), its maximal absorption wavelength at 780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth. Here, we report ECY , a stable deep near-infrared (NIR) fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16% in CH 2 Cl 2 . ECY was further rationally engineered for biological distribution specificity. Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized. By screening this focused library upon intravenous injection to BALB/c mice, ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion, and ECYPEG was found to be a superior candidate for vasculature imaging. They have potentials in intraoperative imaging. & COPY; 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | FLUORESCENCE ; SURGERY ; PROBE |
| 资助项目 | National Natural Science Foundation of China[21908065] ; National Natural Science Foundation of China[22078098] ; National Natural Science Foundation of China[22278138] ; Shanghai Academic Technology Research Leader ; Research Funds of Happiness Flower ECNU[22XD1421000] ; State Key Laboratory of Bioreactor Engineering ; [2020JK2103] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001032705700001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306782]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Youjun |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China 2.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yan,Lu, Xicun,Li, Yi,et al. Spectral and biodistributional engineering of deep near-infrared chromophore[J]. CHINESE CHEMICAL LETTERS,2023,34(9):7. |
| APA | Dong, Yan.,Lu, Xicun.,Li, Yi.,Chen, Weichao.,Yin, Lei.,...&Yang, Youjun.(2023).Spectral and biodistributional engineering of deep near-infrared chromophore.CHINESE CHEMICAL LETTERS,34(9),7. |
| MLA | Dong, Yan,et al."Spectral and biodistributional engineering of deep near-infrared chromophore".CHINESE CHEMICAL LETTERS 34.9(2023):7. |
入库方式： OAI收割
来源：上海药物研究所
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