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Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities

文献类型：期刊论文

作者Wang, Mengyu1,2,3; Yang, Yue2,3; Ke, Changqiang2,3; Yao, Sheng2,3,4,5; Feng, Zheling2,3; Tang, Chunping2,3; Ye, Yang1,2,3,4,6
刊名FITOTERAPIA
出版日期2023-09-01
卷号169页码:11
ISSN号0367-326X
关键词Artemisia verlotorum Verlotolides A -G DFT NMR calculation TDDFT ECD calculation X-ray diffraction Anti-inflammation
DOI10.1016/j.fitote.2023.105560
通讯作者Tang, Chunping() ; Ye, Yang(yye@simm.ac.cn)
英文摘要Seven new sesquiterpenoids (1-7) and 19 known analogues were isolated from the whole plant of Artemisia verlotorum. Their structures were determined by extensive analysis of 1D and 2D NMR and HRESIMS data, electronic circular dichroism (ECD) spectra, density functional theory (DFT) NMR calculations, and time dependent density functional theory (TDDFT) ECD calculations. The absolute configurations of 1, 3, 5 and 7 were confirmed by single crystal X-ray diffraction experiments. Compounds 1 and 2 possess a rarely reported 5/8-bicyclic skeleton, while both compounds 3 and 4 were uncommon iphionane-type sesquiterpenoids. Eudesmane sesquiterpenoids (5-17) reported in this study are all 7,8-cis-lactones, of which, compound 7 represents the first eudesmane sesquiterpene with an oxygen bridge connecting C-5 and C-11. All the compounds were tested in vitro for their anti-inflammatory activities in LPS-stimulated RAW 264.7 murine macrophages. Compound 18 showed a potent inhibitory effect on NO production, with IC50 values of 3.08 & PLUSMN; 0.61 & mu;M.
WOS关键词AQUEOUS CRUDE EXTRACTS ; IN-VITRO ; CHEMICAL-CONSTITUENTS ; ESSENTIAL OIL ; VERLOTIORUM ; LAMOTTE ; ALANTOLIDES ; COMPOSITAE ; VIVO
资助项目Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21920102003] ; Shanghai Pujiang Program[22PJD102] ; Key -Area Research and Development Program of Guangdong Province[2020B0303070002]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:001032456200001
源URL[http://119.78.100.183/handle/2S10ELR8/306785]  
专题新药研究国家重点实验室
通讯作者Tang, Chunping; Ye, Yang
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Mengyu,Yang, Yue,Ke, Changqiang,et al. Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities[J]. FITOTERAPIA,2023,169:11.
APA Wang, Mengyu.,Yang, Yue.,Ke, Changqiang.,Yao, Sheng.,Feng, Zheling.,...&Ye, Yang.(2023).Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities.FITOTERAPIA,169,11.
MLA Wang, Mengyu,et al."Sesquiterpene lactones from Artemisia verlotorum and their anti-inflammatory activities".FITOTERAPIA 169(2023):11.

入库方式： OAI收割

来源：上海药物研究所

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